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GHRP-2

KP-102 · Growth Hormone Releasing Peptide 2

GH SecretagoguePreclinical
From$2.02/mgCompare prices
MW
818g/mol
Formula
C45H55N9O6

GHRP-2, also known as pralmorelin, is a synthetic growth hormone-releasing peptide classified as a growth hormone secretagogue. Researchers primarily study GHRP-2 for its ability to stimulate the release of growth hormone (GH) from the pituitary gland, which is crucial for various physiological processes including muscle growth and metabolism. Key findings indicate that GHRP-2 can significantly elevate plasma GH levels in healthy individuals, although its efficacy may be reduced in those with growth hormone deficiencies. Additionally, studies suggest that GHRP-2 may have diagnostic utility in assessing hypothalamo-pituitary function. Current research continues to explore its potential applications in clinical settings, particularly for conditions related to GH deficiency and metabolic disorders.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC45H55N9O6
Molecular Weight818 g/mol
CAS Number158861-67-7
PubChem CID6918245
ChEMBL IDCHEMBL4297297

Half-Life

SCSubcutaneous

~1-2 hours

IMIntramuscular

~1-2 hours

IVIntravenous

~30 minutes

POOral

Poor bioavailability

The half-life can vary based on individual metabolic factors and the specific formulation used.

Mechanism

Mechanism of Action

GHRP-2 acts primarily through specific GHRP receptors, which are distinct from GHRH receptors and do not exhibit homology with other known G-protein-coupled receptors. The mechanism of action is believed to involve the inhibition of somatostatinergic activity at both the pituitary and hypothalamic levels, potentially enhancing growth hormone (GH) release via a GHRH-mediated mechanism, although the exact signaling pathways remain unclear. GHRP-2 stimulates GH secretion, influencing biological processes such as muscle growth and metabolism, while its effects on other hormones like ACTH and cortisol are also noted.

Research

60 Research Publications

1,768

Total Citations

28

Human/RCT

2.1

Avg. Influence

2025

Latest

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#01

Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats.

AnimalInfluence7.0
182
Researchers observed that GHRP-2 administration reduces inflammation and improves symptoms in arthritic rats by modulating IL-6 levels.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#02

Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks.

In VitroInfluence5.0
160
Researchers observed that GHRP-2 and various ghrelins inhibit food intake in neonatal chicks, indicating their role as GHS receptor agonists.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#03

The somatotropic axis in critical illness: effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion.

HumanInfluence2.0
155
The study demonstrated that continuous infusion of GHRP-2 significantly increases GH secretion and serum IGF-I levels in critically ill adults without altering cortisol levels.
1 microg/kg/hinfusion(human)5 days1 microg/kgbolus(human)not mentioned1 microg/kg/hinfusion(human)not mentioned1 microg/kgi.v.(children)not mentioned1, 4.5 and 9 mg/kg body weight (BW)oral(swine)not mentioned4.5 and 9 mg/kg BWin feed(swine)3 days
PubMed
#04

The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone.

HumanInfluence3.0
134
Researchers observed that combined administration of GHRP-2, TRH, and GnRH in critically ill men resulted in superior endocrine and metabolic effects compared to GHRP-2 alone.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#05

Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH.

HumanInfluence3.0
88
Researchers observed that GHRP-2 and hexarelin stimulate GH secretion and have similar effects on PRL, ACTH, and cortisol levels in humans.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#06

Pituitary responsiveness to GH-releasing hormone, GH-releasing peptide-2 and thyrotrophin-releasing hormone in critical illness.

HumanInfluence1.0
69
Researchers observed that GHRP-2 significantly enhances GH secretion in critically ill patients, indicating its potential therapeutic application in critical care.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#07

The effect of GH-releasing peptide-2 (GHRP-2 or KP 102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist.

In VitroInfluence5.0
61
Researchers found that GHRP-2 (KP 102) significantly stimulates GH secretion in ovine pituitary cells and acts through a different receptor than earlier GH-releasing peptides.
1 microg/kg/hinfusion(human)5 days1 microg/kgbolus(human)not mentioned1 microg/kg/hinfusion(human)not mentioned1 microg/kgi.v.(children)not mentioned1, 4.5 and 9 mg/kg body weight (BW)oral(swine)not mentioned4.5 and 9 mg/kg BWin feed(swine)3 days
PubMed
#08

Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle.

AnimalInfluence3.0
60
The study demonstrated that GHRP-2 prevents arthritis-induced increases in muscle-specific ubiquitin ligases and enhances IGF-I levels in rats.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#09

Identification of the growth-hormone-releasing peptide-2 (GHRP-2) in a nutritional supplement.

Thomas Andreas, et al. · Drug testing and analysis · 2010

Case ReportInfluence2.0
59
Researchers identified GHRP-2 in a nutritional supplement, confirming its growth hormone-releasing properties and highlighting concerns regarding its illicit use in sports.

Key findings

  1. 01GHRP-2 was identified and quantified in tablets marketed as nutritional supplements.
  2. 02This peptide is associated with the release of growth hormone and is prohibited in sports.
  3. 03The study provides analytical methods for detecting GHRP-2 in biological samples, aiding future research.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
#10

Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.

Laferrère Blandine, et al. · The Journal of clinical endocrinology and metabolism · 2005

HumanInfluence1.0
53
Researchers observed that GHRP-2 significantly increases food intake in healthy men, similar to the effects of ghrelin.

Key findings

  1. 01GHRP-2 infusion led to a 35.9% increase in food intake compared to saline.
  2. 02All participants increased their food consumption, even when adjusted for body weight.
  3. 03Serum growth hormone levels rose significantly during GHRP-2 infusion.
0.6 nmol/kg(swine)1 µg/kg/hinfusion(human)5 days1 µg/kg/hinfusion(human)1 µg/kgi.v.(children)
PubMed
Safety

Safety & Handling

Research Gaps

The clinical efficacy of growth hormone secretagogues (GHS) in the management of hypogonadal males remains largely unexamined, with a significant lack of randomized controlled trials assessing their long-term effects and safety profiles. Additionally, the precise mechanisms by which GHRP-2 and other GHS counteract somatostatinergic activity and their potential interactions with other hormonal pathways are not yet fully understood.

Solubility

GHRP-2 is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA as a therapeutic good.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

48 total
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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer