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Sermorelin

GHRH(1-29) · GRF 1-29

GH SecretagoguePreclinical
From$3.75/mgCompare prices
MW
3357.9g/mol
Formula
C149H246N44O42S

Sermorelin is a synthetic peptide that mimics the action of growth hormone-releasing hormone (GHRH), specifically comprising the first 29 amino acids of the natural hormone. Researchers primarily study it for its potential role in stimulating endogenous growth hormone secretion and its implications for conditions related to growth hormone deficiency. Key findings from studies indicate that Sermorelin effectively raises serum insulin-like growth factor 1 (IGF-1) levels, which is a marker of growth hormone activity, and may enhance muscle mass and metabolic outcomes in various populations. Despite promising preclinical evidence, current research is limited, with a notable lack of rigorous clinical trials assessing its long-term safety and efficacy in human subjects.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC149H246N44O42S
Molecular Weight3357.9 g/mol
CAS Number86168-78-7
PubChem CID16132413

Half-Life

SCSubcutaneous

Data limited

IMIntramuscular

Data limited

IVIntravenous

~10 to 20 minutes

INIntranasal

Not applicable

POOral

Poor bioavailability

Due to its peptide nature, Sermorelin is rapidly degraded in the gastrointestinal tract, limiting its oral bioavailability.

Mechanism

Mechanism of Action

Sermorelin, a synthetic analog of growth hormone-releasing hormone (GHRH), primarily acts by binding to the GHRH receptor (GHRHR) on pituitary cells, stimulating the secretion of endogenous growth hormone (GH). This increase in GH subsequently activates the insulin-like growth factor 1 (IGF-1) signaling pathway, promoting anabolic processes such as protein synthesis, tissue repair, and muscle growth. While the exact mechanisms underlying its effects on various biological processes remain to be fully elucidated, it is known to influence pathways involved in cellular regeneration and metabolic regulation.

Research

16 Research Publications

309

Total Citations

8

Human/RCT

1.0

Avg. Influence

2023

Latest

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#01

PEGylation of growth hormone-releasing hormone (GRF) analogues.

Esposito P, et al. · Advanced drug delivery reviews · 2003

AnimalInfluence1.0
71
Researchers observed that PEGylation of sermorelin enhances its stability and bioactivity, resulting in a prolonged pharmacodynamic response in vivo.

Key findings

  1. 01Researchers observed that PEGylation improved the stability and half-life of GRF in the body.
  2. 02The study found that different PEGylated GRF variants showed varying levels of biological activity.
  3. 03Mono-PEGylated versions of GRF demonstrated similar or greater effectiveness in stimulating growth hormone release compared to the unmodified version.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#02

Perinatal growth hormone (GH) physiology: effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.

Human
68
Researchers observed that administration of sermorelin did not significantly affect fetal hGH secretion but resulted in a slight increase in maternal hGH levels in pregnant women.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#03

Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.

In Vitro
33
Researchers observed that an immunoaffinity purification and LC-HRMS/MS method successfully detected growth hormone-releasing hormones, including sermorelin, in human plasma, with insights into their stability and metabolism.
30 or 60 microg/kgsubcutaneous(human)2 microgsubcutaneous(mouse)5 weeks60 or 90 microg/kgsubcutaneous(human)
PubMed
#04

Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.

Animal
31
The study demonstrated a comprehensive method for detecting bioactive peptides, including sermorelin, in blood and urine samples, validated for multiple performance parameters in doping control.
30 or 60 microg/kgsubcutaneous(human)2 microgsubcutaneous(mouse)5 weeks60 or 90 microg/kgsubcutaneous(human)
PubMed
#05

Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.

Review
28
Researchers observed that falsified biopharmaceutical injectables, including sermorelin, pose health risks due to their unregulated nature and potential for containing unlicensed drugs.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#06

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.

Prakash A & Goa K L · BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1999

Case Report
20
Researchers observed that sermorelin effectively stimulates growth hormone secretion in children with idiopathic growth hormone deficiency, resulting in significant increases in height velocity.

Key findings

  1. 01Sermorelin is a useful tool for diagnosing growth hormone deficiency, with fewer false positives compared to other tests.
  2. 02Daily use of sermorelin showed significant increases in height velocity in many children over a 12-month period.
  3. 03The long-term effects of sermorelin on final adult height are still being studied.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#07

Advances in the detection of growth hormone releasing hormone synthetic analogs.

Memdouh Siham, et al. · Drug testing and analysis · 2021

In VitroInfluence1.0
15
Researchers observed that a sensitive detection method for synthetic GHRH analogs, including sermorelin, was developed, identifying 19 metabolites in urine samples.

Key findings

  1. 01Researchers identified 19 major metabolites of four GHRH synthetic analogs in urine samples.
  2. 02The study highlighted the challenges in detecting these substances in anti-doping tests due to their low levels.
  3. 03This research provides important reference materials for future detection efforts in doping control.
30 or 60 microg/kgsubcutaneous(human)2 microgsubcutaneous(mouse)5 weeks60 or 90 microg/kgsubcutaneous(human)
PubMed
#08

Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.

Otin Joanie, et al. · Electrophoresis · 2023

In VitroInfluence1.0
10
Researchers observed that a novel capillary electrophoresis method successfully separated enantiomeric GHRH analogs, including sermorelin, enhancing detection sensitivity.

Key findings

  1. 01The method allowed for the first-time separation of enantiomeric GHRH analogs, which differ by the chirality of one amino acid.
  2. 02A significant increase in detection sensitivity was achieved using a large volume sample stacking technique.
  3. 03The optimized method successfully detected GHRH analogs in urine with a signal enhancement factor of 640.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#09

Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.

In Vitro
9
Researchers observed that optimizing magnetic bead immunopurification improved recovery rates for GHRH analogs, including sermorelin, prior to mass spectrometric analysis.
30 or 60 microg/kgsubcutaneous(human)2 microgsubcutaneous(mouse)5 weeks60 or 90 microg/kgsubcutaneous(human)
PubMed
#10

Probing for peptidic drugs (2-10 kDa) in doping control blood samples.

Animal
8
The study demonstrated that a simplified liquid chromatography and high-resolution mass spectrometry method can effectively detect intact peptides, including sermorelin, in blood samples for doping control.
30 or 60 microg/kgsubcutaneous(human)2 microgsubcutaneous(mouse)5 weeks60 or 90 microg/kgsubcutaneous(human)
PubMed
Safety

Safety & Handling

Research Gaps

No rigorous clinical trials have been conducted to evaluate the long-term safety and efficacy of sermorelin and other growth hormone secretagogues in diverse populations, particularly in athletic and recreational settings. Additionally, the potential risks associated with supraphysiological dosing and the long-term effects of sermorelin on metabolic health and psychological well-being remain poorly understood.

Solubility

Sermorelin is soluble in water and aqueous buffers.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not a controlled substance.

🇦🇺AU

Not approved by the TGA as a medicinal product.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

21 total
1
90
1
99
1
03
1
15
2
16
1
17
2
20
1
21
2
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3
23
1
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1
25
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26
Pricing

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Mechanism

Tools

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Serum Level Visualizer

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer