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Sermorelin

GHRH(1-29) · GRF 1-29

GH SecretagoguePreclinical
From$4.88/mgCompare prices
MW
3357.9g/mol
Formula
C149H246N44O42S

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), classified as a growth hormone secretagogue. Researchers primarily study it for its potential to stimulate endogenous growth hormone production and its implications in conditions related to growth hormone deficiency. Key findings from the literature indicate that sermorelin administration can significantly elevate serum insulin-like growth factor 1 (IGF-1) levels, which serves as a surrogate marker for growth hormone activity, and it has been associated with improvements in lean body mass and fat loss in specific populations. Despite promising preclinical evidence and emerging interest in its applications, current research is limited, with a notable lack of large-scale clinical trials to fully establish its safety and efficacy in broader contexts.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC149H246N44O42S
Molecular Weight3357.9 g/mol
CAS Number86168-78-7
PubChem CID16132413

Half-Life

SCSubcutaneous

Data limited

IMIntramuscular

Data limited

IVIntravenous

~10 to 20 minutes

INIntranasal

Not applicable

POOral

Poor bioavailability

Due to its peptide nature, Sermorelin is rapidly degraded in the gastrointestinal tract, limiting its oral bioavailability.

Mechanism

Mechanism of Action

Sermorelin acts as a synthetic analog of growth hormone-releasing hormone (GHRH), binding to GHRH receptors on pituitary somatotrophs, leading to the stimulation of endogenous growth hormone (GH) secretion. This increase in GH subsequently enhances insulin-like growth factor 1 (IGF-1) signaling, activating pathways such as the PI3K/Akt and mTOR pathways, which are crucial for promoting tissue regeneration, muscle growth, and metabolic processes. While the primary mechanisms are understood, the full spectrum of sermorelin's effects and its interactions with other signaling pathways remain to be fully elucidated.

Research

7 Research Publications

203

Total Citations

5

Human/RCT

1.0

Avg. Influence

2023

Latest

Sort
#01

PEGylation of growth hormone-releasing hormone (GRF) analogues.

Esposito P, et al. · Advanced drug delivery reviews · 2003

ReviewInfluence1.0
71
The study demonstrated that PEGylation of sermorelin enhances its stability and biological activity, potentially improving its pharmacodynamic response in vivo.

Key findings

  1. 01Researchers observed that PEGylation improved the stability and half-life of GRF in the body.
  2. 02The study found that different PEGylated GRF variants showed varying levels of biological activity.
  3. 03Mono-PEGylated versions of GRF demonstrated similar or greater effectiveness in stimulating growth hormone release compared to the unmodified version.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#02

Perinatal growth hormone (GH) physiology: effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.

Human
68
Researchers observed that administration of sermorelin to pregnant women did not significantly affect fetal growth hormone secretion, suggesting a lack of transplacental passage of the growth hormone-releasing factor.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#03

Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.

Human
29
The study reported the seizure of falsified biopharmaceutical injectables, including sermorelin, indicating a health risk due to unlicensed drugs entering the European market.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#04

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.

Prakash A & Goa K L · BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1999

Unknown
20
The study demonstrated that sermorelin is effective in diagnosing growth hormone deficiency in children and promotes significant catch-up growth in those with idiopathic growth hormone deficiency.

Key findings

  1. 01Sermorelin is a useful tool for diagnosing growth hormone deficiency, with fewer false positives compared to other tests.
  2. 02Daily use of sermorelin showed significant increases in height velocity in many children over a 12-month period.
  3. 03The long-term effects of sermorelin on final adult height are still being studied.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#05

Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.

Otin Joanie, et al. · Electrophoresis · 2023

HumanInfluence1.0
10
Researchers observed that a capillary electrophoresis method successfully separated enantiomeric GHRH analogs, including sermorelin, enhancing detection sensitivity for doping analysis.

Key findings

  1. 01The method allowed for the first-time separation of enantiomeric GHRH analogs, which differ by the chirality of one amino acid.
  2. 02A significant increase in detection sensitivity was achieved using a large volume sample stacking technique.
  3. 03The optimized method successfully detected GHRH analogs in urine with a signal enhancement factor of 640.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#06

Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.

Human
3
The study demonstrated that GHRP/SERM therapy significantly increases serum IGF-1 levels in hypogonadal men, suggesting its potential benefits in improving body composition.
100 mcgnot specified(human)not specified1 microg/kg/hinfusion(human)5 days1 microg/kg/hinfusion(human)21 hours1 microg/kgi.v.(children)not specified100 microg/kgnot specified(rats)8 days10 nMnot specified(ovine)not specified
PubMed
#07

In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.

González-López Nicolás Mateo, et al. · Biomedical chromatography : BMC · 2023

Human
2
Researchers observed that specific GHRP and sermorelin peptides exhibit stability in biological matrices, suggesting their potential as internal standards for peptide quantification in doping analysis.

Key findings

  1. 01Researchers observed that the matrix effect and sample pretreatment significantly influence peptide recovery in biological samples.
  2. 02GHRP-4, GHRP-6, and Sermorelin (22-29) were identified as stable internal standards for quantifying peptides.
  3. 03The study established a unique profile for each peptide regarding its stability and protein binding.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials specifically evaluating the efficacy and safety of sermorelin in diverse patient populations have been published. Additionally, the long-term effects of sermorelin therapy, particularly in athletic and recreational settings, remain unclear, as current studies primarily focus on short-term outcomes and controlled dosing regimens.

Solubility

Sermorelin is soluble in water and aqueous buffers.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not a controlled substance.

🇦🇺AU

Not approved by the TGA as a medicinal product.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

21 total
1
90
1
99
1
03
1
15
2
16
1
17
2
20
1
21
2
22
3
23
1
24
1
25
4
26
Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer