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Sermorelin

GHRH(1-29) · GRF 1-29

GH SecretagoguePreclinical
From$5.00/mgCompare prices
MW
3357.9g/mol
Formula
C149H246N44O42S

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), primarily composed of the first 29 amino acids of the natural hormone, and is classified as a growth hormone secretagogue. Researchers primarily study it for its potential role in stimulating endogenous growth hormone production and its implications in conditions such as hypogonadism and metabolic disorders. Key findings from the literature indicate that sermorelin can activate insulin-like growth factor 1 (IGF-1) signaling pathways, which are crucial for tissue repair and metabolic regulation, while also showing promise in enhancing body composition and recovery from injuries. Despite these insights, current research is limited by a lack of extensive clinical trials, highlighting the need for further investigation into its safety and efficacy in human populations. As interest in therapeutic peptides grows, studies suggest that sermorelin may play a significant role in future approaches to musculoskeletal care and metabolic health.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC149H246N44O42S
Molecular Weight3357.9 g/mol
CAS Number86168-78-7
PubChem CID16132413

Half-Life

SCSubcutaneous

Data limited

IMIntramuscular

Data limited

IVIntravenous

~10 to 20 minutes

INIntranasal

Not applicable

POOral

Poor bioavailability

Due to its peptide nature, Sermorelin is rapidly degraded in the gastrointestinal tract, limiting its oral bioavailability.

Mechanism

Mechanism of Action

Sermorelin acts as a synthetic analog of growth hormone-releasing hormone (GHRH), binding to GHRH receptors on pituitary somatotrophs, leading to the stimulation of endogenous growth hormone (GH) secretion. This process activates the insulin-like growth factor 1 (IGF-1) signaling pathway, which plays a crucial role in promoting tissue growth, regeneration, and metabolic processes. While the overall mechanism is understood, specific details regarding additional signaling pathways influenced by sermorelin remain to be fully elucidated.

Research

7 Research Publications

202

Total Citations

6

Human/RCT

1.0

Avg. Influence

2023

Latest

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#01

PEGylation of growth hormone-releasing hormone (GRF) analogues.

Esposito P, et al. · Advanced drug delivery reviews · 2003

AnimalInfluence1.0
71
Researchers observed that PEGylation of sermorelin analogs can enhance their stability and biological activity, potentially improving their pharmacodynamic response in vivo.

Key findings

  1. 01Researchers observed that PEGylation improved the stability and half-life of GRF in the body.
  2. 02The study found that different PEGylated GRF variants showed varying levels of biological activity.
  3. 03Mono-PEGylated versions of GRF demonstrated similar or greater effectiveness in stimulating growth hormone release compared to the unmodified version.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#02

Perinatal growth hormone (GH) physiology: effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.

Human
68
Researchers observed that administration of sermorelin did not significantly affect fetal hGH secretion, suggesting that fetal hGH levels are independent of maternal GH-releasing factor during late pregnancy.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#03

Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.

Case Report
28
The study demonstrated that Operation Resistance identified a small number of falsified biopharmaceutical injectables, including sermorelin, highlighting the risks associated with unregulated peptide use.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#04

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.

Prakash A & Goa K L · BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1999

Human
20
Researchers observed that sermorelin effectively stimulates growth hormone secretion in children with idiopathic growth hormone deficiency, leading to significant increases in height velocity.

Key findings

  1. 01Sermorelin is a useful tool for diagnosing growth hormone deficiency, with fewer false positives compared to other tests.
  2. 02Daily use of sermorelin showed significant increases in height velocity in many children over a 12-month period.
  3. 03The long-term effects of sermorelin on final adult height are still being studied.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#05

Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.

Otin Joanie, et al. · Electrophoresis · 2023

In VitroInfluence1.0
10
The study demonstrated a novel capillary electrophoresis method that successfully separates enantiomeric GHRH analogs, including sermorelin, enhancing detection sensitivity.

Key findings

  1. 01The method allowed for the first-time separation of enantiomeric GHRH analogs, which differ by the chirality of one amino acid.
  2. 02A significant increase in detection sensitivity was achieved using a large volume sample stacking technique.
  3. 03The optimized method successfully detected GHRH analogs in urine with a signal enhancement factor of 640.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#06

Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.

Human
3
Researchers observed that GHRP/SERM therapy significantly increased serum IGF-1 levels in hypogonadal men, indicating potential benefits for conditions associated with decreased GH secretion.
1 microg/kg bodyweightintravenous(human)not mentioned30 microg/kg bodyweightsubcutaneous(human)once daily30 microg/kg bodyweightsubcutaneous(human)once daily100 mcgnot mentioned(human)not mentioned
PubMed
#07

In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.

González-López Nicolás Mateo, et al. · Biomedical chromatography : BMC · 2023

In Vitro
2
The study demonstrated that certain GHRP and GHRH-related peptides, including sermorelin, exhibit stability in biological matrices, making them suitable as internal standards for quantification.

Key findings

  1. 01Researchers observed that the matrix effect and sample pretreatment significantly influence peptide recovery in biological samples.
  2. 02GHRP-4, GHRP-6, and Sermorelin (22-29) were identified as stable internal standards for quantifying peptides.
  3. 03The study established a unique profile for each peptide regarding its stability and protein binding.
120 microg/kg of body weightintraperitoneally(rat)1 mg/kg of body weightintraperitoneally(rat)300 nmol/kg(mouse)9 weeks6 mg/kg body weightintravenously(growing pig)seven days3 and 30 microg/kg(rat)90 microgramsintravenously(human)1 microg/kgintravenously(human)1 microgram/kgintravenously(human)2 microg/kgintravenously(human)
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted specifically on the efficacy and safety of sermorelin in the treatment of hypogonadism or athletic performance enhancement. Additionally, the long-term effects of sermorelin therapy on metabolic health and body composition remain largely unknown, as well as the detailed mechanisms underlying its action in various clinical contexts.

Solubility

Sermorelin is soluble in water and aqueous buffers.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not a controlled substance.

🇦🇺AU

Not approved by the TGA as a medicinal product.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

21 total
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90
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99
1
03
1
15
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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer