Wiki · Profile

Hexarelin

Examorelin · EP-23905

GH SecretagoguePreclinical

MW: 887g/mol
Formula: C47H58N12O6

Hexarelin is a synthetic growth hormone-releasing peptide that belongs to the class of growth hormone secretagogues (GHS), designed to stimulate the release of growth hormone from the pituitary gland. Researchers primarily study hexarelin for its potential roles in promoting longevity, cardiovascular health, and metabolic regulation. Key findings indicate that hexarelin not only enhances growth hormone release but also exerts direct cardioprotective effects through specific receptors in the heart, suggesting a multifaceted role in cardiovascular physiology. Additionally, studies suggest that hexarelin may influence insulin sensitivity and lipid metabolism, highlighting its relevance in diabetes and related complications. Current research continues to explore its safety, efficacy, and broader therapeutic applications in various clinical contexts.

Chemical Profile

Chemical Structure

Formula	C47H58N12O6
Molecular Weight	887 g/mol
CAS Number	140703-51-1
PubChem CID	6918297

Half-Life

SCSubcutaneous

Data limited

IMIntramuscular

Data limited

IVIntravenous

~55 to 70 minutes

POOral

Poor bioavailability

Hexarelin's short half-life necessitates frequent administration for sustained effects.

Mechanism

Mechanism of Action

Hexarelin acts primarily through the growth hormone secretagogue receptor (GHSR), stimulating growth hormone (GH) release via the activation of the phospholipase C (PLC) signaling pathway, which leads to increased intracellular calcium levels and subsequent GH secretion. Additionally, hexarelin interacts with the non-GHSR receptor CD36, mediating cardioprotective effects through pathways such as peroxisome proliferator-activated receptor gamma (PPAR-γ) regulation, influencing lipid metabolism and insulin sensitivity. While the exact mechanisms of action are not fully understood, hexarelin's effects extend beyond GH release, suggesting potential roles in cardiovascular protection and metabolic regulation.

Research

80 Research Publications

3,438

Total Citations

Human/RCT

3.1

Avg. Influence

2025

Latest

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01Top

#01

Growth hormone in obesity.

ReviewInfluence10.0

336

The study demonstrated that hexarelin elicits greater GH responses in obese patients compared to traditional stimuli, highlighting its potential role in obesity management.

1 microgram/kgintravenous(human)not mentioned2 microgram kg-1intravenous(human)not mentioned250 microg/kg s. c. twice dailysubcutaneous(dog)6 weeks25 micrograms/kgintravenous(rat)not mentioned10(-7) mol/lnot mentioned(rat)24 h4 microg/kg per hintravenous(rat)1.5 h

PubMed

02Top

#02

Central control of penile erection: role of the paraventricular nucleus of the hypothalamus.

AnimalInfluence3.0

218

Researchers observed that the paraventricular nucleus of the hypothalamus plays a crucial role in controlling erectile function in male rats through the activation of oxytocinergic neurons.

PubMed

03Top

#03

Ghrelin regulates proliferation and differentiation of osteoblastic cells.

In VitroInfluence9.0

202

Researchers observed that both ghrelin and hexarelin significantly stimulated osteoblast proliferation and differentiation in rat calvarial osteoblast cultures, while EP-40737 showed an antiproliferative effect.

25 micrograms/kgi.v.(rat)not mentioned100 micrograms/hcontinuous infusion(rat)6, 30 or 174 h100 microgramsi.v.(human)not mentioned80 microgram/kg, b.i.d., s.c.s.c.(rat)30 days2 microgram kg-1i.v.(human)not mentioned250 micrograms/kgi.v.(dog)not mentioned

PubMed

#04

The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals.

AnimalInfluence6.0

158

Researchers observed that oxytocinergic neurons in the paraventricular nucleus are crucial for controlling erectile function and male sexual behavior in mammals.

PubMed

#05

The CD36-PPARγ Pathway in Metabolic Disorders.

Maréchal Loïze, et al. · International journal of molecular sciences · 2018

ReviewInfluence10.0

147

The study demonstrated that hexarelin activates PPARγ via CD36, suggesting its role in regulating lipid and energy metabolism in metabolic disorders.

Key findings

01Researchers found that activating PPARγ can improve insulin resistance in diabetic patients.
02The study identified GHRP as a potent activator of PPARγ through the scavenger receptor CD36.
03Findings suggest that the GHRP-CD36-PPARγ pathway could help manage various metabolic disorders.

PubMed

#06

GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats.

AnimalInfluence3.0

139

Researchers observed that hexarelin effectively stimulates GH secretion in both infant and adult rats, showing similar effectiveness to GHRP-6.

PubMed

#07

Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation.

In VitroInfluence2.0

118

Researchers observed that hexarelin stimulates cardiomyocyte proliferation in a dose-dependent manner, indicating its potential cardiovascular effects independent of GH secretion.

PubMed

#08

Identification and characterization of a new growth hormone-releasing peptide receptor in the heart.

AnimalInfluence5.0

115

The study demonstrated that hexarelin induces a dose-dependent increase in coronary perfusion pressure in rat hearts, suggesting a specific cardiac receptor's involvement.

2 microgram kg-1intravenous(human)25 micrograms/kgintravenous(rat)5 micrograms/kgintravenous(rat)80 micrograms/kg, b.i.d. s.c.subcutaneous(rat)100 micrograms/hcontinuous infusion(rat)6, 30 or 174 h

PubMed

#09

The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin.

HumanInfluence4.0

101

The study demonstrated that hexarelin stimulates the hypothalamo-pituitary-adrenal axis in humans, likely through the release of arginine vasopressin.

1 microgram/kgintravenous(human)1 microgintracerebroventricular(rat)10 microgintravenous(human)2.0 microg/kgintravenous(human)25 micrograms/kgintravenous(rat)100 μg/kgsubcutaneous(rat)30 days330 μg/kgintraperitoneal(rat)5 microg/kgintravenous(rat)50 microg/m2/hintravenous(human)

PubMed

#10

Growth hormone-releasing peptides and their analogs.

ReviewInfluence2.0

Researchers observed that growth hormone-releasing peptides, including hexarelin, effectively stimulate GH release in both animals and humans through specific receptors in the pituitary and hypothalamus.

PubMed

Safety

Safety & Handling

Research Gaps

No long-term, rigorously controlled studies have been conducted to evaluate the safety and efficacy of hexarelin in diverse clinical scenarios, particularly regarding its potential impact on cancer incidence and mortality. Additionally, the exact mechanisms by which hexarelin exerts its cardioprotective effects via the non-GHSR CD36 receptor remain unclear, warranting further investigation.

Solubility

Hexarelin is soluble in water and DMSO, but poorly soluble in acetonitrile.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for medical use. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA for therapeutic use.

🇬🇧UK

Not approved by the MHRA for medical use.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

48 total

Pricing

Price Comparison

BESTRCpeptidesEU
10mg
$54.00
Price/mg
$5.40/mg
View
Research Peptides UKUK
2mg
$12.64
Price/mg
$6.32/mg
View
Geo PeptidesUS
5mg
$32.99
Price/mg
$6.60/mg
View
Ruo BioUS
5mg
$34.00
Price/mg
$6.80/mg
View
MoglabsUS
5mg
$38.00
Price/mg
$7.60/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTRCpeptidesEU	10mg	$54.00	$5.40/mg	View
Research Peptides UKUK	2mg	$12.64	$6.32/mg	View
Geo PeptidesUS	5mg	$32.99	$6.60/mg	View
Ruo BioUS	5mg	$34.00	$6.80/mg	View
MoglabsUS	5mg	$38.00	$7.60/mg	View

Top 5 of 24 offers from 21 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer