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Ipamorelin

NNC 26-0161

GH SecretagoguePhase II
From$2.20/mgCompare prices
MW
711.9g/mol
Formula
C38H49N9O5

Ipamorelin is a synthetic pentapeptide classified as a growth hormone secretagogue, derived from a series of compounds designed to stimulate growth hormone release. Researchers primarily study ipamorelin for its potential role in enhancing tissue regeneration and recovery in various medical fields, particularly orthopaedics and sports medicine. Key findings from the most cited studies indicate that ipamorelin exhibits high potency in stimulating growth hormone release without significantly affecting other hormones such as ACTH or cortisol, suggesting a selective action on growth hormone pathways. Preclinical evidence indicates that when combined with other peptides like CJC-1295, ipamorelin may improve muscle recovery and function in animal models. Despite these promising results, the current research status highlights a lack of robust clinical trials in humans, necessitating further investigation to establish its safety and efficacy in therapeutic applications.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC38H49N9O5
Molecular Weight711.9 g/mol
CAS Number170851-70-4
PubChem CID9831659

Half-Life

SCSubcutaneous

~2 hours

INIntranasal

Not applicable

POOral

Poor bioavailability

Ipamorelin's pharmacokinetics are characterized by a short half-life and limited oral bioavailability, necessitating injectable administration for effective use.

Mechanism

Mechanism of Action

Ipamorelin acts as a selective agonist for growth hormone secretagogue receptors (GHS-R), stimulating the release of growth hormone (GH) from the pituitary gland. This process primarily activates the insulin-like growth factor 1 (IGF-1) signaling pathway, which is crucial for tissue regeneration, muscle repair, and metabolic regulation. While the exact molecular mechanisms remain partially understood, ipamorelin's specificity for GH release without significantly affecting other hormones like ACTH and cortisol suggests a unique modulation of endocrine signaling pathways.

Research

33 Research Publications

795

Total Citations

9

Human/RCT

1.9

Avg. Influence

2020

Latest

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#01

Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry.

In VitroInfluence1.0
86
Researchers observed that a method for extracting and detecting growth hormone releasing peptides, including ipamorelin, from human urine could enhance doping control efforts by identifying known and unknown metabolites.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#02

Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.

AnimalInfluence3.0
85
Researchers observed that ipamorelin treatment increased body fat in both GH-deficient and GH-intact mice, indicating GH-independent mechanisms for adiposity stimulation.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#03

Pharmacological characterisation of a new oral GH secretagogue, NN703.

AnimalInfluence5.0
63
Researchers observed that NN703, a novel orally active growth hormone secretagogue derived from ipamorelin, effectively stimulated GH release in both swine and dogs, demonstrating promising pharmacological properties.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#04

Seabream ghrelin: cDNA cloning, genomic organization and promoter studies.

AnimalInfluence1.0
60
Researchers observed that the seabream ghrelin gene exhibits tissue-specific expression regulated by growth hormone and ipamorelin, with implications for understanding the ghrelin/GHSR system in teleosts.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#05

Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass spectrometry.

In VitroInfluence1.0
59
Researchers observed that a novel screening assay effectively detects prohibited small peptides, including ipamorelin, in urine, enhancing doping control methodologies.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#06

Metabolism of growth hormone releasing peptides.

Animal
50
The study demonstrated that 28 metabolites of various growth hormone releasing peptides, including ipamorelin, were identified in urine, aiding in the development of doping control strategies.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#07

Novel orally active growth hormone secretagogues.

Animal
37
The study demonstrated that novel growth hormone secretagogues derived from ipamorelin exhibited oral bioavailability and maintained in vivo potency in swine, indicating potential for further development.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#08

A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography.

Animal
37
The study demonstrated a novel method for the extraction and detection of growth hormone releasing peptides, including ipamorelin, in equine and human urine using high-throughput LC-MS/MS.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#09

Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus.

Venkova Kalina, et al. · The Journal of pharmacology and experimental therapeutics · 2009

AnimalInfluence2.0
33
Researchers observed that ipamorelin accelerates gastrointestinal transit and increases fecal output in a rodent model of postoperative ileus, suggesting its potential role in gastrointestinal recovery.

Key findings

  1. 01A single dose of ipamorelin decreased the time to the first bowel movement in rats after surgery.
  2. 02Repetitive dosing of ipamorelin significantly increased food intake and body weight over 48 hours.
  3. 03The study indicates that intravenous infusions of ipamorelin may improve digestive symptoms in patients recovering from surgery.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
#10

A stable meta-carborane enables the generation of boron-rich peptide agonists targeting the ghrelin receptor.

In VitroInfluence1.0
32
Researchers observed that a stable meta-carborane enabled the development of boron-rich peptide agonists targeting the ghrelin receptor, enhancing the potential for tumor-directed boron delivery in cancer therapy.
30 nmol/kgintravenous(not specified)not specified10(-8) Min vitro(not specified)not specified
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been published specifically evaluating the efficacy and safety of ipamorelin in treating musculoskeletal injuries. Additionally, the long-term effects of ipamorelin on metabolic health and potential interactions with other medications remain unknown.

Solubility

Ipamorelin is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for clinical use. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA for therapeutic use.

🇬🇧UK

Not approved by the MHRA for medicinal use.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

48 total
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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer