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Ipamorelin

NNC 26-0161

GH SecretagoguePhase II

MW: 711.9g/mol
Formula: C38H49N9O5

Ipamorelin is a synthetic pentapeptide classified as a growth hormone secretagogue, derived from a series of compounds designed to stimulate the release of growth hormone (GH) from the pituitary gland. Researchers primarily study ipamorelin for its potential applications in enhancing muscle recovery, promoting tissue regeneration, and influencing bone mineral content. Key findings from studies indicate that ipamorelin effectively stimulates GH release without significantly affecting other hormones like ACTH and cortisol, and it has been shown to increase bone mineral content in animal models. Current research status reveals a growing interest in its therapeutic potential, particularly in the fields of orthopaedics and sports medicine, although substantial clinical evidence is still lacking.

Chemical Profile

Chemical Structure

Formula	C38H49N9O5
Molecular Weight	711.9 g/mol
CAS Number	170851-70-4
PubChem CID	9831659

Half-Life

SCSubcutaneous

~2 hours

INIntranasal

Not applicable

POOral

Poor bioavailability

Ipamorelin's pharmacokinetics are characterized by a short half-life and limited oral bioavailability, necessitating injectable administration for effective use.

Mechanism

Mechanism of Action

Ipamorelin acts as a selective agonist for growth hormone secretagogue receptors (GHS-R), stimulating the release of growth hormone (GH) from the anterior pituitary gland. This activation primarily engages the IGF-1 signaling pathway, promoting tissue regeneration, muscle hypertrophy, and bone mineralization. While the precise mechanisms remain to be fully elucidated, ipamorelin's influence on GH release appears to be independent of significant effects on other hormones such as ACTH and cortisol.

Research

48 Research Publications

1,086

Total Citations

Human/RCT

1.9

Avg. Influence

2026

Latest

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01Top

#01

Ipamorelin, the first selective growth hormone secretagogue.

In VitroInfluence6.0

Researchers observed that ipamorelin is a selective growth hormone secretagogue with high potency for GH release, showing promise for future clinical applications due to its specificity.

0.5 mg/kg per daysubcutaneous(rat)12 weeks0.03 mg/kgintravenous(human)up to 7 days100 microg/kgsubcutaneous(rat)3 months0.01-1 mg/kgintravenous(rat)48 h5 or 30 µgnot specified(fish)21 days50 nmol/kgnot specified(pig)not specified

PubMed

02Top

#02

Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry.

In VitroInfluence1.0

Researchers observed an efficient extraction method for various GHRPs from human urine, allowing for retrospective evaluation of unknown metabolites using high-resolution mass spectrometry.

PubMed

03Top

#03

Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.

AnimalInfluence2.0

The study demonstrated that growth hormone secretagogues like Ipamorelin increased body fat and serum leptin levels in both GH-deficient and GH-intact mice through GH-independent mechanisms.

PubMed

#04

Pharmacological characterisation of a new oral GH secretagogue, NN703.

AnimalInfluence5.0

Researchers observed that NN703, a novel oral GH secretagogue derived from ipamorelin, effectively stimulated GH release in swine and dogs, demonstrating significant body weight gain in rats after administration.

PubMed

#05

Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass spectrometry.

In VitroInfluence1.0

The study demonstrated a high-resolution mass spectrometry method for screening prohibited small peptides in urine, achieving low limits of detection and validating its applicability for doping controls.

PubMed

#06

Seabream ghrelin: cDNA cloning, genomic organization and promoter studies.

In VitroInfluence1.0

The study demonstrated the cloning and characterization of seabream ghrelin, revealing its tissue-specific expression in the stomach and regulation by growth hormone and ipamorelin.

PubMed

#07

Metabolism of growth hormone releasing peptides.

In Vitro

Researchers observed the identification of urinary metabolites from growth hormone-releasing peptides, including Ipamorelin, which may aid in doping control analysis.

PubMed

#08

Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin.

In VitroInfluence1.0

Researchers observed that ipamorelin and other GHRPs can be detected in urine after nasal administration, providing insights for anti-doping control measures.

PubMed

#09

Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.

In Vitro

The study demonstrated a sensitive assay for detecting prohibited peptides in urine using direct injection and mass spectrometry, achieving limits of detection suitable for doping control.

PubMed

#10

Novel orally active growth hormone secretagogues.

Animal

The study demonstrated the discovery of novel orally active growth hormone secretagogues derived from Ipamorelin, with some compounds showing oral bioavailability in dogs.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to assess the efficacy and safety of ipamorelin in treating musculoskeletal injuries. Additionally, the long-term effects of ipamorelin on bone mineral content and overall metabolic health in humans remain unknown, as well as the specific mechanisms by which it influences growth hormone release and its potential interactions with other hormonal pathways.

Solubility

Ipamorelin is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for clinical use. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA for therapeutic use.

🇬🇧UK

Not approved by the MHRA for medicinal use.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

47 total

Pricing

Price Comparison

BESTAlpha PeptidesUS
10mg
$21.99
$19.79
Price/mg
$2.20$1.98/mg
View−10% · PEPSTACK10
Step OneUS
10mg
$33.00
Price/mg
$3.30/mg
View
Geo PeptidesUS
10mg
$34.99
Price/mg
$3.50/mg
View
Puratek PeptidesUS
10mg
$37.95
$34.16
Price/mg
$3.80$3.42/mg
View−10% · PEPSTACKS10
Research Peptides UKUK
5mg
$18.99
Price/mg
$3.80/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTAlpha PeptidesUS	10mg	$21.99$19.79	$2.20$1.98/mg	View−10% · PEPSTACK10
Step OneUS	10mg	$33.00	$3.30/mg	View
Geo PeptidesUS	10mg	$34.99	$3.50/mg	View
Puratek PeptidesUS	10mg	$37.95$34.16	$3.80$3.42/mg	View−10% · PEPSTACKS10
Research Peptides UKUK	5mg	$18.99	$3.80/mg	View

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer