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GHRP-6

Growth Hormone Releasing Peptide 6 · His-DTrp-Ala-Trp-DPhe-Lys-NH2

GH SecretagoguePreclinical

MW: 873g/mol
Formula: C46H56N12O6

Growth hormone-releasing peptide-6 (GHRP-6) is a synthetic hexapeptide classified as a growth hormone-releasing peptide that stimulates the secretion of growth hormone from the pituitary gland. Researchers primarily study GHRP-6 for its potential roles in regenerative medicine and its effects on various physiological processes, including cell migration and metabolic reprogramming. Key findings from recent studies indicate that GHRP-6 hydrogel treatment enhances the survival of renal tubular epithelial cells during acute kidney injury by activating specific metabolic pathways, while also demonstrating protective effects against multiple organ failure in preclinical models. Additionally, azapeptide derivatives of GHRP-6 have shown promise as selective ligands for the CD36 receptor, suggesting potential applications in atherosclerosis management. Current research continues to explore the diverse therapeutic implications of GHRP-6 and its analogs across various health conditions.

Chemical Profile

Chemical Structure

Formula	C46H56N12O6
Molecular Weight	873 g/mol
PubChem CID	4345065

Half-Life

SCSubcutaneous

~2 hours

IMIntramuscular

~2 hours

IVIntravenous

~20 to 30 minutes

POOral

Poor bioavailability

The half-life can vary based on the specific formulation and individual metabolic factors.

Mechanism

Mechanism of Action

GHRP-6 acts primarily through specific GHRP receptors located in the pituitary and hypothalamic regions, stimulating growth hormone (GH) secretion by counteracting somatostatinergic activity and potentially engaging GHRH-mediated mechanisms. It activates the mTOR-P70 signaling pathway, promoting metabolic reprogramming and enhancing cell survival in renal tubular epithelial cells during acute kidney injury. While the complete mechanism remains partially understood, evidence suggests involvement in various biological processes, including cell migration, proliferation, and metabolic regulation.

Research

73 Research Publications

2,523

Total Citations

Human/RCT

2.1

Avg. Influence

2014

Latest

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01Top

#01

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.

HumanInfluence3.0

202

Researchers observed that GHRP-6-induced GH secretion was completely blocked in patients with hypothalamopituitary disconnection, highlighting its primary action at the hypothalamic level.

120 microg/kgintraperitoneally(rat)300 nmol/kg(mouse)9 weeks6 mg/kgintravenously(growing pig)seven days3 and 30 microg/kg(rat)90 microgramsi.v.(human)1 microg/kgi.v.(human)2 microg/kgi.v.(human)1 microgram/kgi.v.(human)

PubMed

02Top

#02

GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults.

HumanInfluence3.0

192

The study demonstrated that the GHRH/GHRP-6 test is a reliable method for diagnosing growth hormone deficiency in adults, outperforming the insulin tolerance test.

PubMed

03Top

#03

Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity.

HumanInfluence4.0

168

The study demonstrated that the combined administration of GHRP-6 and GHRH induced a significantly greater growth hormone peak in obese human subjects compared to GHRH alone.

300 nmol/kgoral(mouse)9 weeks70 mg/Kgintraperitoneal(rat)single injection1 and 10 microg/kgintravenous(rat)single injection3 and 30 microg/kgintravenous(rat)single injection2 microg/kgintravenous(human)bolus administration6 mg/kg body weightintravenous(pig)seven days100 mcgintravenous(human)single injection1 microgram/kgintravenous(human)separate days10(-8) M to 10(-5) Min vitro(bovine)not mentioned10(-9) Min vitro(cow)not mentioned1 microgram, 4 micrograms and 25 micrograms/kgintravenous(rat)not mentioned0.5 mg/kg per daysubcutaneous(rat)12 weeks20 nmoles/mouseintraperitoneal(mouse)14 days15 micromin vitro(rat)10 min

PubMed

#04

Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.

AnimalInfluence5.0

126

Researchers observed that ghrelin and GHRP-6 accelerate gastric emptying and transit in rats, with ghrelin being more potent than GHRP-6.

PubMed

#05

Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man.

HumanInfluence5.0

122

Researchers observed that GHRP-6 stimulates growth hormone, ACTH, and cortisol release in normal men, enhancing stage 2 sleep without affecting slow-wave sleep.

PubMed

#06

Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice.

AnimalInfluence2.0

104

The study demonstrated that GHRP-6 accelerates gastric emptying in septic mice, suggesting its potential as a prokinetic agent in this condition.

PubMed

#07

Parallel studies of His-DTrp-Ala-Trp-DPhe-Lys-NH2 and human pancreatic growth hormone-releasing factor-44-NH2 in rat primary pituitary cell monolayer culture.

Sartor O, et al. · Endocrinology · 1985

AnimalInfluence2.0

104

Researchers studied two peptides, GH-RP-6 and hpGRF-44, that stimulate growth hormone (GH) release in rat pituitary cells. They found that these peptides work through different mechanisms and that their effects can be influenced by calcium levels and the presence of rat serum.

Key findings

01Researchers observed that GH-RP-6 and hpGRF-44 both release GH but under different optimal conditions.
02The study found that GH-RP-6 has a higher effective dose compared to hpGRF-44.
03Researchers noted that the two peptides can enhance each other's GH release effects.

PubMed

#08

Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor.

In VitroInfluence1.0

102

The study demonstrated that GHRP-6 regulates Pit-1 expression in pituitary cells, indicating its role in the transcriptional activation of growth hormone secretion.

PubMed

#09

Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP-6.

HumanInfluence4.0

The study demonstrated that GHRP-6 effectively stimulates growth hormone secretion in humans, with responses being independent of sex and age, but influenced by adrenergic pathways.

PubMed

#10

Absence of growth hormone (GH) secretion after the administration of either GH-releasing hormone (GHRH), GH-releasing peptide (GHRP-6), or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection.

Case ReportInfluence1.0

Researchers observed that children with neonatal pituitary stalk transection show no growth hormone secretion after GHRP-6 administration, indicating the importance of hypothalamic factors in GH regulation.

PubMed

Safety

Safety & Handling

Research Gaps

No comprehensive human trials have been conducted to explore the long-term effects and safety of GHRP-6 in various therapeutic contexts, particularly in the treatment of acute kidney injury and multiple organ failure. Additionally, the precise mechanisms by which GHRP-6 influences metabolic reprogramming in renal tubular epithelial cells and its interaction with other hypothalamic factors remain unclear.

Solubility

GHRP-6 is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for medical use. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA for therapeutic use.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

49 total

Pricing

Price Comparison

BESTPeptiLab USAUS
10mg
$13.79
Price/mg
$1.38/mg
View
Research Peptides UKUK
5mg
$10.10
Price/mg
$2.02/mg
View
Research Peptides UKUK
5mg
$12.69
Price/mg
$2.54/mg
View
Ruo BioUS
5mg
$16.00
Price/mg
$3.20/mg
View
MoglabsUS
5mg
$16.00
Price/mg
$3.20/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTPeptiLab USAUS	10mg	$13.79	$1.38/mg	View
Research Peptides UKUK	5mg	$10.10	$2.02/mg	View
Research Peptides UKUK	5mg	$12.69	$2.54/mg	View
Ruo BioUS	5mg	$16.00	$3.20/mg	View
MoglabsUS	5mg	$16.00	$3.20/mg	View

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer