Gonadorelin
GnRH · Gonadotropin-Releasing Hormone · Factrel
- MW
- 1182.3g/mol
- Formula
- C55H75N17O13
Gonadorelin is a synthetic decapeptide classified as a gonadotropin-releasing hormone (GnRH) analog, originally derived from the hypothalamus. Researchers primarily study it for its role in regulating reproductive functions and its potential applications in treating conditions like hypogonadotropic hypogonadism and enhancing reproductive performance in livestock. Key findings from recent studies indicate that gonadorelin can effectively induce ovulation in various animal models, including goats and queens, and may also inhibit tumorigenesis in colorectal cancer models. Current research continues to explore innovative delivery methods and the peptide's broader therapeutic implications, particularly in reproductive health and oncology.
Chemical Profile
| Formula | C55H75N17O13 |
| Molecular Weight | 1182.3 g/mol |
| CAS Number | 33515-09-2 |
| PubChem CID | 638793 |
Half-Life
Data limited
Data limited
~2 to 4 minutes
Data limited
Poor bioavailability
Gonadorelin is rapidly metabolized and cleared from the circulation, necessitating specific routes of administration for sustained effects.
Mechanism of Action
Gonadorelin acts as a synthetic analog of gonadotropin-releasing hormone (GnRH), binding to GnRH receptors (GnRHR) on the anterior pituitary gland, which activates the phospholipase C (PLC) signaling pathway, leading to increased intracellular calcium levels and subsequent secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This stimulation promotes gonadal function, influencing processes such as ovulation and steroidogenesis. While the primary mechanism is well-characterized, additional nuances in signaling pathways and receptor interactions may not be fully understood.
Safety & Handling
Research Gaps
No comprehensive human trials have been conducted to evaluate the long-term effects of gonadorelin treatment on reproductive health and hormonal balance. Additionally, the specific mechanisms by which gonadorelin modulates immune responses and tumorigenesis in colorectal cancer remain unclear and warrant further investigation.
Solubility
Gonadorelin is soluble in water and aqueous buffers but has limited solubility in organic solvents like acetonitrile and DMSO.
Storage & Handling
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
Legal Status
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Approved by the FDA for specific diagnostic and therapeutic uses. Not a controlled substance.
🇦🇺AU
Listed in the Australian Register of Therapeutic Goods for specific uses. Not a controlled substance.
🇬🇧UK
Approved by the MHRA for specific medical uses. Not a controlled substance.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Community Insights
Publications per Year
47 totalTools
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer