Pitocin · Syntocinon
Oxytocin is a peptide hormone classified as a neuropeptide, primarily produced in the hypothalamus and released by the posterior pituitary gland. Researchers primarily study oxytocin for its roles in social behavior, maternal bonding, and its physiological effects during childbirth. Key findings from recent studies suggest that oxytocin not only facilitates maternal nurturing and social bonding but also influences various social behaviors through its action on specific neural circuits. Additionally, preclinical evidence indicates that oxytocin may play a role in modulating social functioning in disorders characterized by social impairments, such as autism spectrum disorder. Current research is focused on elucidating the complex mechanisms of oxytocin's action in the brain and its potential therapeutic applications in various psychiatric and neurodevelopmental conditions.
| Formula | C43H66N12O12S2 |
| Molecular Weight | 1007.2 g/mol |
| CAS Number | 50-56-6 |
| PubChem CID | 439302 |
| ChEMBL ID | CHEMBL2369424 |
~3-5 minutes
~3-5 minutes
~15-30 minutes
Poor bioavailability
Oxytocin is rapidly degraded by oxytocinase, limiting its duration of action.
Oxytocin primarily acts through the oxytocin receptor (OTR), a G-protein coupled receptor (GPCR), which activates intracellular signaling pathways such as the phospholipase C (PLC) pathway, leading to increased intracellular calcium levels and subsequent activation of protein kinase C (PKC). This signaling cascade is involved in various biological processes, including myometrial contraction during parturition, modulation of social behaviors, and inhibition of feeding behavior. Although the full extent of OTR signaling mechanisms and their implications in different physiological contexts are not completely understood, the receptor's role in mediating oxytocin's effects on behavior and reproductive functions is well established.
4,777
Total Citations
13
Human/RCT
4.7
Avg. Influence
2025
Latest
The study demonstrated that oxytocin and vasopressin are crucial for social attachment behaviors in prairie voles, with receptor density correlating with monogamous behaviors.
Researchers observed that oxytocin and vasopressin are critical for social recognition processes in mammals, as evidenced by various animal models.
The study demonstrated the synthesis of selective peptide agonists and antagonists for oxytocin and vasopressin receptors, highlighting their potential as research tools and therapeutic agents.
Researchers observed that abnormalities in oxytocin or vasopressin neurotransmission may contribute to features of autism, supported by evidence from gene targeting studies in rodents.
The study demonstrated that oxidation of oxytocin can lead to significant structural and biological changes, affecting its pharmacokinetics and activity.
Researchers observed that endogenous peptides, including oxytocin, have limited passage through the blood-brain barrier but can influence its permeability.
Quintana Daniel S & Guastella Adam J · Trends in cognitive sciences · 2020
Researchers explored the role of oxytocin, often linked to social behavior, by examining its evolutionary background and developmental changes. They found that oxytocin acts as an allostatic hormone, helping to regulate both social interactions and responses to various environmental challenges.
Key findings
Researchers observed that oxytocin and vasopressin modulate various social behaviors in the brain, influencing maternal bonding and social communication.
Researchers observed that early experiences and exposure to oxytocin have sexually dimorphic effects on behavior in prairie voles.
Researchers observed that peptides can modulate gonadotropin levels at the anterior pituitary, although the precise mechanisms and interactions remain unclear.
No comprehensive human trials have been conducted to evaluate the long-term effects of oxytocin on social behavior and psychiatric disorders, particularly in diverse populations. Additionally, the precise mechanisms by which oxytocin and alpha-MSH interact within the hypothalamic circuitry remain unclear, limiting our understanding of their combined influence on complex behaviors.
Solubility
Oxytocin is soluble in water and saline solutions.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Approved for medical use. Not a controlled substance.
🇺🇸US
FDA approved for medical use in labor induction and postpartum hemorrhage. Not a controlled substance.
🇦🇺AU
TGA approved for medical use. Not a controlled substance.
🇬🇧UK
MHRA approved for medical use. Not a controlled substance.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
46 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTBiolab ShopUS | 10mg | $42.40 | $4.24/mg | |
Ruo BioUS | 5mg | $22.00 | $4.40/mg | |
MoglabsUS | 5mg | $24.00 | $4.80/mg | |
Glacier AminosUS | 10mg | $50.39 | $5.04/mg | |
Welli LabsUS | 10mg | $54.99 | $5.50/mg |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer