Pitocin · Syntocinon
Oxytocin is a neuropeptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland, known for its roles in childbirth, lactation, and social bonding. Researchers primarily study oxytocin for its influence on social behaviors, including maternal nurturing, pair bonding, and social reward mechanisms. Key findings suggest that oxytocin enhances the salience of social stimuli and facilitates social memory, with distinct effects observed across different species. Recent studies have also highlighted the complex neural circuits involved in oxytocin signaling and its potential implications for understanding social impairments in conditions such as autism spectrum disorder. Current research continues to explore the multifaceted roles of oxytocin in both physiological and psychological contexts, utilizing advanced molecular techniques to investigate its mechanisms of action.
| Formula | C43H66N12O12S2 |
| Molecular Weight | 1007.2 g/mol |
| CAS Number | 50-56-6 |
| PubChem CID | 439302 |
| ChEMBL ID | CHEMBL2369424 |
~3-5 minutes
~3-5 minutes
~15-30 minutes
Poor bioavailability
Oxytocin is rapidly degraded by oxytocinase, limiting its duration of action.
Oxytocin primarily exerts its effects through the oxytocin receptor (OTR), a G-protein coupled receptor (GPCR) that activates the phospholipase C (PLC) signaling pathway, leading to increased intracellular calcium levels and subsequent activation of protein kinase C (PKC). This signaling cascade is involved in various biological processes, including maternal bonding, social behaviors, and modulation of stress responses. While the precise mechanisms of OTR signaling in different contexts are still being elucidated, its role in enhancing social reward and memory, as well as its interaction with other neuropeptides like alpha-MSH, highlights its complex influence on behavior and physiology.
4,366
Total Citations
11
Human/RCT
4.8
Avg. Influence
2025
Latest
The study demonstrated that monogamous prairie voles exhibit a higher density of oxytocin receptors in the nucleus accumbens, which is crucial for partner preference formation.
Researchers observed that oxytocin and vasopressin are critical for social recognition processes in mammals, influencing olfactory-based social memory.
The study demonstrated advancements in the development of selective peptide agonists and antagonists for oxytocin and vasopressin receptors, highlighting their potential as research tools and therapeutic agents.
Researchers observed that abnormalities in oxytocin and vasopressin neurotransmission may contribute to social impairments in autism, supported by evidence from animal studies.
The study demonstrated that oxidation of oxytocin and other therapeutic peptides can lead to significant structural and biological changes, impacting their efficacy.
Researchers observed that endogenous oxytocin is extracted in low amounts across the blood-brain barrier, influencing brain function and permeability.
Quintana Daniel S & Guastella Adam J · Trends in cognitive sciences · 2020
Researchers explored the role of oxytocin, often linked to social behavior, by examining its evolutionary background and developmental changes. They found that oxytocin acts as an allostatic hormone, helping to regulate both social interactions and responses to various environmental challenges.
Key findings
Researchers observed that early experiences and hormonal manipulations can lead to long-lasting, sexually dimorphic behavioral effects in prairie voles, potentially mediated by oxytocin and arginine vasopressin.
Researchers observed that oxytocin and vasopressin modulate various social behaviors through specific neural circuits, with implications for improving social functioning in disorders like autism spectrum disorder.
Researchers observed that various neuropeptides, including oxytocin, play modulatory roles in learning and memory processes, particularly under stress conditions.
No comprehensive human trials have been conducted to assess the long-term effects of oxytocin on social behaviors in diverse populations, particularly in individuals with social impairments such as autism spectrum disorder. Additionally, the precise mechanisms by which oxytocin and vasopressin interact with other neuropeptides, such as alpha-MSH, in regulating complex behaviors remain poorly understood.
Solubility
Oxytocin is soluble in water and saline solutions.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Approved for medical use. Not a controlled substance.
🇺🇸US
FDA approved for medical use in labor induction and postpartum hemorrhage. Not a controlled substance.
🇦🇺AU
TGA approved for medical use. Not a controlled substance.
🇬🇧UK
MHRA approved for medical use. Not a controlled substance.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
47 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTRuo BioUS | 5mg | $22.00 | $4.40/mg | |
MoglabsUS | 5mg | $24.00 | $4.80/mg | |
Welli LabsUS | 10mg | $54.99 | $5.50/mg | |
AMP PeptidesUS | 10mg | $58.00 | $5.80/mg | |
EZ PeptidesUS | 10mg | $58.00 | $5.80/mg |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer