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Kisspeptin-10

KP-10 · Metastin(112-121)

Hormonal AxisPhase III
From$4.00/mgCompare prices
MW
1302.4g/mol
Formula
C63H83N17O14

Kisspeptin-10 is a neuropeptide derived from the Kiss1 gene, primarily known for its role in regulating reproductive hormone release. Researchers primarily study kisspeptin-10 for its effects on stimulating the secretion of follicle-stimulating hormone, luteinizing hormone, and testosterone, which may have implications for fertility treatments. Key findings indicate that kisspeptin-10 can influence ovarian function and may play a role in maintaining endocrine balance during pregnancy, while also showing potential effects on cardiac health and bone metabolism. Current research continues to explore its metabolic pathways and therapeutic applications, particularly in the context of reproductive health and other physiological processes.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC63H83N17O14
Molecular Weight1302.4 g/mol
CAS Number374675-21-5
PubChem CID25240297
ChEMBL IDCHEMBL4297297

Half-Life

SCSubcutaneous

Data limited

IVIntravenous

~30 minutes

POOral

Poor bioavailability

KP-10 is rapidly degraded in the bloodstream, limiting its half-life and necessitating specific routes of administration for effective delivery.

Mechanism

Mechanism of Action

Kisspeptin-10 (Kp-10) exerts its biological effects primarily through binding to the G-protein-coupled receptor GPR54, leading to the activation of downstream signaling pathways such as the Dusp18-mediated dephosphorylation of Src at Tyr 416. This interaction results in the modulation of various biological processes, including the regulation of gonadotropin release, apoptosis, and osteoclast activity, thereby influencing reproductive functions and bone metabolism. While the precise mechanisms of Kp-10's actions in different tissues are still being elucidated, its role in these signaling pathways highlights its potential therapeutic applications.

Research

69 Research Publications

2,238

Total Citations

8

Human/RCT

2.8

Avg. Influence

2025

Latest

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#01

Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

AnimalInfluence23.0
480
The study demonstrated that kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis, increasing plasma luteinizing hormone, follicle-stimulating hormone, and testosterone levels in male rats.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#02

GPR54 and kisspeptin in reproduction.

Tena-Sempere Manuel · Human reproduction update · 2006

ReviewInfluence3.0
201
The study demonstrated that kisspeptins, including kisspeptin-10, are crucial regulators of the reproductive system through their action on the GPR54 receptor.

Key findings

  1. 01Researchers observed that mutations in the GPR54 gene can lead to delayed puberty and reproductive issues in humans.
  2. 02The study highlighted that kisspeptins are powerful stimulators of reproductive hormone activity across various species.
  3. 03Researchers found that the KiSS-1/GPR54 system plays a key role in activating neurons that control reproductive hormone release during puberty.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#03

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

HumanInfluence17.0
170
The study demonstrated that intravenous kisspeptin-10 administration in healthy men resulted in a rapid and dose-dependent increase in luteinizing hormone (LH) levels and pulse frequency.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#04

Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells.

In VitroInfluence2.0
125
The study demonstrated that kisspeptin-10 directly stimulated luteinizing hormone secretion from bovine and porcine anterior pituitary cells at higher concentrations, indicating its role in reproductive hormone regulation.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#05

Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation.

In VitroInfluence3.0
110
The study demonstrated that kisspeptin-10 inhibits angiogenesis in vitro and in vivo by suppressing VEGF expression and disrupting signaling pathways in human umbilical vein endothelial cells.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#06

Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells.

In VitroInfluence3.0
89
The study demonstrated that Kisspeptin-10 directly stimulates growth hormone and prolactin secretion from bovine anterior pituitary cells, with varying responses based on age.
10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)
PubMed
#07

The role of kisspeptin and GPR54 in the hippocampus.

Animal
57
The study demonstrated that kisspeptin-10 activation of GPR54 in rat hippocampal granule cells enhances excitatory synaptic responses, indicating a novel role in synaptic transmission.
10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)
PubMed
#08

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.

In VitroInfluence1.0
57
Researchers observed that structural modifications in kisspeptin-10 can significantly alter its biological activity and receptor interactions, suggesting potential for developing new therapeutic agents.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#09

Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro.

In VitroInfluence2.0
56
The study demonstrated that Kisspeptin-10 inhibits angiogenesis in human placental vessels and endothelial cells by reducing proliferation and migration without affecting cell viability.
10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)
PubMed
#10

The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats.

Animal
49
Researchers observed that kisspeptin-10 and oxytocin exhibit antioxidant effects, reducing cellular damage in the ovaries and uterus of ischemia-reperfusion injured rats.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
Safety

Safety & Handling

Research Gaps

No comprehensive human clinical trials have been conducted to assess the long-term effects of kisspeptin-10 on reproductive health and cardiac function. Additionally, the precise mechanisms by which kisspeptin-10 influences myocardial structure and function, as well as its interaction with other hormonal pathways in humans, remain unclear.

Solubility

Kisspeptin-10 is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

48 total
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Pricing

Price Comparison

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  • Peptide CraftersUS
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  • Swiss ChemsUS
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    Price/mg
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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer