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Kisspeptin-10

KP-10 · Metastin(112-121)

Hormonal AxisPhase III
From$4.00/mgCompare prices
MW
1302.4g/mol
Formula
C63H83N17O14

Kisspeptin-10 is a neuropeptide derived from the Kiss1 gene, primarily involved in the regulation of reproductive hormone release. Researchers primarily study kisspeptin-10 for its role in stimulating the secretion of follicle-stimulating hormone and luteinizing hormone, which are critical for fertility. Key findings indicate that kisspeptin-10 can increase testosterone levels and has potential implications in both reproductive physiology and sports doping, leading to its inclusion on the World Anti-Doping Agency's Prohibited List. Additionally, studies have highlighted its effects on ovarian and cardiac functions, suggesting a broader physiological impact beyond reproduction. Current research continues to explore its metabolic pathways and potential therapeutic applications, particularly in the context of reproductive health and cardiovascular function.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC63H83N17O14
Molecular Weight1302.4 g/mol
CAS Number374675-21-5
PubChem CID25240297
ChEMBL IDCHEMBL4297297

Half-Life

SCSubcutaneous

Data limited

IVIntravenous

~30 minutes

POOral

Poor bioavailability

KP-10 is rapidly degraded in the bloodstream, limiting its half-life and necessitating specific routes of administration for effective delivery.

Mechanism

Mechanism of Action

Kisspeptin-10 exerts its effects primarily through the activation of G protein-coupled receptors (GPCRs), specifically the Kiss1 receptor (KISS1R), which initiates signaling cascades involving the phospholipase C (PLC) pathway, leading to increased intracellular calcium levels and activation of protein kinase C (PKC). This signaling promotes the release of gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby influencing reproductive processes including puberty onset and fertility. Although the precise mechanisms underlying its effects on cardiac function and antioxidant activity are not fully understood, kisspeptin-10 has been implicated in modulating gene expression and metabolic pathways related to heart health and oxidative stress response.

Research

69 Research Publications

2,238

Total Citations

8

Human/RCT

2.8

Avg. Influence

2025

Latest

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#01

Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

AnimalInfluence23.0
480
The study demonstrated that kisspeptin-10 potently stimulates the hypothalamic-pituitary-gonadal axis, increasing plasma luteinizing hormone, follicle-stimulating hormone, and testosterone in male rats.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#02

GPR54 and kisspeptin in reproduction.

Tena-Sempere Manuel · Human reproduction update · 2006

ReviewInfluence3.0
201
The study demonstrated that kisspeptins, including kisspeptin-10, are crucial regulators of the reproductive system via their action on the GPR54 receptor.

Key findings

  1. 01Researchers observed that mutations in the GPR54 gene can lead to delayed puberty and reproductive issues in humans.
  2. 02The study highlighted that kisspeptins are powerful stimulators of reproductive hormone activity across various species.
  3. 03Researchers found that the KiSS-1/GPR54 system plays a key role in activating neurons that control reproductive hormone release during puberty.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#03

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

HumanInfluence17.0
170
The study demonstrated that intravenous kisspeptin-10 administration in healthy men rapidly increased serum LH concentration and pulse frequency in a dose-dependent manner.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#04

Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells.

In VitroInfluence2.0
125
The study demonstrated that kisspeptin-10 directly stimulated luteinizing hormone secretion from bovine and porcine anterior pituitary cells at higher concentrations, indicating its role in reproductive hormone regulation.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#05

Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation.

In VitroInfluence3.0
110
The study demonstrated that kisspeptin-10 inhibits angiogenesis in vitro and in vivo by suppressing VEGF expression and disrupting signaling pathways in human umbilical vein endothelial cells.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#06

Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells.

In VitroInfluence3.0
89
The study demonstrated that Kisspeptin-10 directly stimulates growth hormone and prolactin secretion from bovine anterior pituitary cells, with varying responses based on age.
10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)
PubMed
#07

The role of kisspeptin and GPR54 in the hippocampus.

Animal
57
Researchers observed that activation of GPR54 by kisspeptin-10 enhances excitatory synaptic transmission in rat hippocampal granule cells through postsynaptic mechanisms linked to the MAP kinase system.
10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)
PubMed
#08

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.

In VitroInfluence1.0
57
The study demonstrated that structural modifications of kisspeptin-10 can significantly alter its receptor activity and functional responses, emphasizing the importance of specific amino acid positions.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
#09

Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro.

In VitroInfluence2.0
56
The study demonstrated that Kisspeptin-10 inhibits angiogenesis in human placental vessels and endothelial cells by reducing proliferation and migration without affecting cell viability.
10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)
PubMed
#10

The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats.

Animal
49
Researchers observed that kisspeptin-10 and oxytocin administration reduced cellular damage in the ovary and uterus of ischemia-reperfusion injured rats, indicating their antioxidant potential.
2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to evaluate the long-term effects of kisspeptin-10 on reproductive health and hormone regulation. Additionally, the precise mechanisms by which kisspeptin-10 influences cardiac function and its potential therapeutic applications in heart disease remain unclear.

Solubility

Kisspeptin-10 is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

48 total
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Pricing

Price Comparison

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer