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Kisspeptin-10

KP-10 · Metastin(112-121)

Hormonal AxisPhase III

MW: 1302.4g/mol
Formula: C63H83N17O14

Kisspeptin-10 is a neuropeptide derived from the KiSS-1 gene, classified as a potent regulator of the reproductive hormone axis. Researchers primarily study kisspeptin-10 for its role in stimulating the release of gonadotropins, such as follicle-stimulating hormone and luteinizing hormone, which are crucial for reproductive function. Key findings indicate that kisspeptin-10 not only influences reproductive hormones but also plays a role in metabolic processes, such as modulating glucose homeostasis and impacting bone health through its interaction with the GPR54 receptor. Current research continues to explore its diverse physiological effects and potential implications in reproductive health, obesity, and metabolic disorders, while also addressing concerns regarding its misuse in sports due to its testosterone-increasing effects.

Chemical Profile

Chemical Structure

Formula	C63H83N17O14
Molecular Weight	1302.4 g/mol
CAS Number	374675-21-5
PubChem CID	25240297
ChEMBL ID	CHEMBL4297297

Half-Life

SCSubcutaneous

Data limited

IVIntravenous

~30 minutes

POOral

Poor bioavailability

KP-10 is rapidly degraded in the bloodstream, limiting its half-life and necessitating specific routes of administration for effective delivery.

Mechanism

Mechanism of Action

Kisspeptin-10 binds to the G protein-coupled receptor GPR54, activating downstream signaling pathways that include the recruitment of Dusp18 phosphatase, leading to the dephosphorylation of Src at Tyr 416. This interaction plays a crucial role in regulating reproductive hormone secretion, specifically enhancing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and modulating osteoclast activity to prevent bone loss. While the mechanisms of action are well-characterized in certain contexts, some aspects of kisspeptin-10's broader metabolic roles and interactions remain to be fully elucidated.

Research

89 Research Publications

2,914

Total Citations

Human/RCT

3.1

Avg. Influence

2025

Latest

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Filter

01Top

#01

Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

AnimalInfluence24.0

483

The study demonstrated that kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis in male rats, increasing plasma luteinizing hormone, follicle-stimulating hormone, and testosterone levels.

25 nmol/kgintraperitoneal(mouse)21 days3 nmolintracerebroventricular(rat)not mentioned0.01-3.0 μg/kgintravenous(human)not mentioned4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)not mentioned

PubMed

02Top

#02

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.

In VitroInfluence19.0

361

Researchers observed that kisspeptin antagonists inhibited GnRH neuron activity and reduced luteinizing hormone secretion, highlighting kisspeptin's role in reproductive regulation.

5 nmolintracerebroventricular(rat)30 to 60 min post-injection50 nMnot mentioned(chondrocytes)not mentioned100 nMnot mentioned(chondrocytes)not mentioned10-100 or 500 nMnot mentioned(HUVECs)24 hours10-100 or 500 nMnot mentioned(HUVECs)48 hours

PubMed

03Top

#03

GPR54 and kisspeptin in reproduction.

Tena-Sempere Manuel · Human reproduction update · 2006

ReviewInfluence4.0

206

Researchers observed that kisspeptins, including kisspeptin-10, play a critical role in regulating puberty and reproductive functions through the GPR54 receptor.

Key findings

01Researchers observed that mutations in the GPR54 gene can lead to delayed puberty and reproductive issues in humans.
02The study highlighted that kisspeptins are powerful stimulators of reproductive hormone activity across various species.
03Researchers found that the KiSS-1/GPR54 system plays a key role in activating neurons that control reproductive hormone release during puberty.

PubMed

#04

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

HumanInfluence14.0

173

The study demonstrated that kisspeptin-10 administration significantly increased LH pulse frequency and testosterone levels in healthy men.

PubMed

#05

Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells.

AnimalInfluence2.0

126

The study demonstrated that kisspeptin-10 directly stimulates luteinizing hormone secretion from bovine and porcine anterior pituitary cells, albeit with a weaker effect compared to GnRH.

PubMed

#06

Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation.

In VitroInfluence4.0

111

The study demonstrated that kisspeptin-10 inhibits tumor angiogenesis by suppressing VEGF expression and blocking key signaling pathways in endothelial cells.

PubMed

#07

Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells.

AnimalInfluence3.0

Researchers observed that kisspeptin-10 directly stimulates growth hormone and prolactin secretion from cultured bovine anterior pituitary cells, with varying effects based on the age of the calves.

PubMed

#08

Kisspeptin modulates fertilization capacity of mouse spermatozoa.

In VitroInfluence6.0

Researchers observed that kisspeptin-10 enhances intracellular calcium levels in mouse sperm, suggesting its involvement in the fertilization process.

PubMed

#09

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.

AnimalInfluence1.0

The study demonstrated that modifications at positions 6 and 10 of kisspeptin-10 critically affect its action at the KISS1 receptor, influencing receptor affinity and functional activity.

PubMed

#10

Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro.

HumanInfluence3.0

The study demonstrated that kisspeptin-10 inhibits angiogenesis in human placental vessels and endothelial cells, reducing proliferation and migration without affecting cell viability.

PubMed

Safety

Safety & Handling

Research Gaps

No long-term human trials have been conducted to assess the sustained effects of kisspeptin-10 on reproductive health and metabolic functions. Additionally, the precise mechanisms by which kisspeptin-10 influences the gut-pancreatic axis and its potential interactions with other hormonal pathways remain unclear.

Solubility

Kisspeptin-10 is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

50 total

Pricing

Price Comparison

BESTModern ResearchUS
10mg
$39.99
Price/mg
$4.00/mg
View
RCpeptidesEU
10mg
$43.20
Price/mg
$4.32/mg
View
Eternal PeptidesUS
10mg
$45.99
Price/mg
$4.60/mg
View
XL PeptidesUK
5mg
$25.39
Price/mg
$5.08/mg
View
Sports Technology LabsUS
5mg
$25.49
Price/mg
$5.10/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTModern ResearchUS	10mg	$39.99	$4.00/mg	View
RCpeptidesEU	10mg	$43.20	$4.32/mg	View
Eternal PeptidesUS	10mg	$45.99	$4.60/mg	View
XL PeptidesUK	5mg	$25.39	$5.08/mg	View
Sports Technology LabsUS	5mg	$25.49	$5.10/mg	View

Top 5 of 19 offers from 20 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer