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Kisspeptin-10

KP-10 · Metastin(112-121)

Hormonal AxisPhase III

MW: 1302.4g/mol
Formula: C63H83N17O14

Kisspeptin-10 is a peptide hormone derived from the KiSS-1 gene and functions as a natural ligand for the G protein-coupled receptor GPR54. Researchers primarily study kisspeptin-10 for its significant role in regulating reproductive hormones, including luteinizing hormone and follicle-stimulating hormone, which are crucial for fertility. Key findings indicate that kisspeptin-10 can stimulate testosterone production and has been linked to the onset of puberty, while also playing a role in the regulation of ovarian functions and bone metabolism. Current research is focused on understanding its metabolic pathways and potential implications in both reproductive health and conditions such as osteoporosis, as well as its inclusion in anti-doping regulations due to its performance-enhancing effects in sports.

Chemical Profile

Chemical Structure

Formula	C63H83N17O14
Molecular Weight	1302.4 g/mol
CAS Number	374675-21-5
PubChem CID	25240297
ChEMBL ID	CHEMBL4297297

Half-Life

SCSubcutaneous

Data limited

IVIntravenous

~30 minutes

POOral

Poor bioavailability

KP-10 is rapidly degraded in the bloodstream, limiting its half-life and necessitating specific routes of administration for effective delivery.

Mechanism

Mechanism of Action

Kisspeptin-10 (Kp-10) exerts its biological effects primarily through binding to the G protein-coupled receptor GPR54, activating signaling pathways that regulate the gonadotropic axis and reproductive function. This interaction stimulates the release of gonadotropins (LH and FSH) via the GnRH signaling pathway, while also influencing other processes such as osteoclast activity through Dusp18-mediated dephosphorylation of Src, although the complete mechanistic details remain to be fully elucidated.

Research

76 Research Publications

2,782

Total Citations

Human/RCT

3.3

Avg. Influence

2025

Latest

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Filter

01Top

#01

Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

AnimalInfluence24.0

481

Researchers observed that kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis, increasing plasma LH, FSH, and testosterone in male rats.

5 nmolintracerebroventricular(rat)30 to 60 min post-injection50 nMnot mentioned(chondrocytes)not mentioned100 nMnot mentioned(chondrocytes)not mentioned10-100 or 500 nMnot mentioned(HUVECs)24 hours10-100 or 500 nMnot mentioned(HUVECs)48 hours

PubMed

02Top

#02

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.

In VitroInfluence19.0

361

Researchers observed that kisspeptin antagonists inhibited GnRH neuron activity and reduced luteinizing hormone secretion, highlighting kisspeptin's role in reproductive regulation.

PubMed

03Top

#03

GPR54 and kisspeptin in reproduction.

Tena-Sempere Manuel · Human reproduction update · 2006

ReviewInfluence4.0

205

Researchers observed that kisspeptin-10 plays a crucial role in activating the gonadotrophic axis and regulating reproductive function through its interaction with the GPR54 receptor.

Key findings

01Researchers observed that mutations in the GPR54 gene can lead to delayed puberty and reproductive issues in humans.
02The study highlighted that kisspeptins are powerful stimulators of reproductive hormone activity across various species.
03Researchers found that the KiSS-1/GPR54 system plays a key role in activating neurons that control reproductive hormone release during puberty.

PubMed

#04

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

HumanInfluence17.0

171

Researchers observed that kisspeptin-10 administration increases LH pulse frequency and serum testosterone levels in healthy men.

PubMed

#05

Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells.

In VitroInfluence2.0

125

The study demonstrated that kisspeptin-10 directly stimulated luteinizing hormone secretion from bovine and porcine anterior pituitary cells at higher concentrations, indicating its role in reproductive hormone regulation.

2500 IUintravenous(equine)single dose3 nmolintracerebroventricular(rat)single dose100 nMnot specified(chondrocyte)not specified10 μMnot specified(Hypo-E22 cells)not specified10-100 or 500 nMnot specified(HUVECs)24 hours0.1, 1, 10, and 100 nMnot specified(R366.4 cells)72 hours

PubMed

#06

Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation.

In VitroInfluence4.0

110

Researchers observed that kisspeptin-10 inhibits tumor angiogenesis by suppressing VEGF expression and blocking focal adhesion kinase and Rho GTPase activation in human umbilical vein endothelial cells.

3 nmolintracerebroventricular(rat)100-1000 nMperipheral(rat)10 μM(cell line)0, 1, 10, and 100 ng/ml(cell line)10-100 or 500 nM(cell line)24 hours

PubMed

#07

Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells.

In VitroInfluence3.0

The study demonstrated that Kisspeptin-10 directly stimulates growth hormone and prolactin secretion from bovine anterior pituitary cells, with varying responses based on age.

10 ng/ml(feline)3 nmolintracerebroventricular(rat)1000 nM(bovine)10,000 nM(bovine)100 nM(bovine)1000 nM(bovine)10,000 nM(bovine)25 nmol/kgintraperitoneal(female mice)21 days0.01-3.0 μg/kgintravenous(human)4 μg/kg · hintravenous(human)22.5 h1.5 μg/kg · hintravenous(human)

PubMed

#08

Kisspeptin modulates fertilization capacity of mouse spermatozoa.

In VitroInfluence6.0

Researchers observed that kisspeptin-10 enhances intracellular calcium levels in mouse sperm, suggesting its involvement in the fertilization process.

PubMed

#09

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.

In VitroInfluence1.0

The study demonstrated that specific amino acid substitutions in kisspeptin-10 significantly alter its receptor activity and structural conformation, highlighting critical positions for its action at the kisspeptin receptor.

PubMed

#10

Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro.

In VitroInfluence3.0

The study demonstrated that kisspeptin-10 inhibits angiogenesis in human placental vessels and endothelial cells by reducing proliferation and migration without affecting cell viability.

3 nmolintracerebroventricular(rat)100-1000 nMperipheral(rat)10 μM(cell line)0, 1, 10, and 100 ng/ml(cell line)10-100 or 500 nM(cell line)24 hours

PubMed

Safety

Safety & Handling

Research Gaps

No comprehensive human clinical trials have been conducted to assess the long-term effects of kisspeptin-10 on reproductive health and its potential therapeutic applications. Additionally, the precise molecular mechanisms by which kisspeptin-10 influences osteoclast activity and bone metabolism remain unclear, particularly in human subjects.

Solubility

Kisspeptin-10 is soluble in water and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

50 total

Pricing

Price Comparison

BESTModern ResearchUS
10mg
$39.99
Price/mg
$4.00/mg
View
RCpeptidesEU
10mg
$43.20
Price/mg
$4.32/mg
View
Geo PeptidesUS
10mg
$45.99
Price/mg
$4.60/mg
View
Peptide CraftersUS
5mg
$30.00
Price/mg
$6.00/mg
View
Soma ChemsUS
10mg
$59.99
Price/mg
$6.00/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTModern ResearchUS	10mg	$39.99	$4.00/mg	View
RCpeptidesEU	10mg	$43.20	$4.32/mg	View
Geo PeptidesUS	10mg	$45.99	$4.60/mg	View
Peptide CraftersUS	5mg	$30.00	$6.00/mg	View
Soma ChemsUS	10mg	$59.99	$6.00/mg	View

Top 5 of 15 offers from 17 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer