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Epithalon

Epitalon · Epithalamin · Ala-Glu-Asp-Gly

Anti-Aging & LongevityPreclinical
From$1.50/mgCompare prices
MW
390.35g/mol
Formula
C14H22N4O9

Epithalon, also known as Epitalon, is a synthetic tetrapeptide composed of the amino acids alanine, glutamic acid, aspartic acid, and glycine (AEDG), originally derived from a bovine pineal gland extract. Researchers primarily study Epithalon for its potential geroprotective and neuroendocrine effects, particularly in relation to aging and cellular longevity. Key findings from various studies indicate that Epithalon may enhance telomerase activity, leading to telomere elongation in human somatic cells, and has been shown to prolong lifespan and reduce the incidence of tumors in transgenic mouse models. Additionally, studies suggest that Epithalon modulates gene expression and influences various biological pathways, including those related to oxidative stress and cellular repair mechanisms. Despite the promising preclinical evidence, the clinical application of Epithalon remains limited, with a need for further research to fully elucidate its mechanisms and therapeutic potential.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC14H22N4O9
Molecular Weight390.35 g/mol
CAS Number307297-39-8
PubChem CID219042

Half-Life

POOral

Poor bioavailability

Pharmacokinetic data is limited, and the compound is rapidly metabolized.

Mechanism

Mechanism of Action

Epithalon (Ala-Glu-Asp-Gly) enhances telomerase activity, leading to telomere elongation in human somatic cells, which may involve reactivation of the telomerase gene. It also modulates gene expression, influencing pathways such as the PI3K/Akt and MAPK pathways, and exhibits antioxidant and neuroprotective effects, potentially affecting melatonin synthesis and interleukin-2 levels. While its specific receptor interactions and comprehensive mechanisms remain partially understood, its geroprotective properties and effects on cellular aging are well-documented.

Research

54 Research Publications

229

Total Citations

6

Human/RCT

1.1

Avg. Influence

2025

Latest

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#01

Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.

In VitroInfluence2.0
27
Researchers observed that the addition of epithalon peptide to human fetal fibroblast cultures induced telomerase activity and telomere elongation, suggesting potential for lifespan extension in cell populations.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#02

Peptide promotes overcoming of the division limit in human somatic cell.

In Vitro
17
The study demonstrated that Epithalon prolonged the proliferative potential of human fetal fibroblasts by inducing telomerase activity and elongating telomeres.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#03

Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.

Anisimov S V, et al. · Bulletin of experimental biology and medicine · 2002

Animal
13
Researchers observed that epithalon modulated the expression of 98 gene clones in the hearts of mice, indicating specific effects on gene expression.

Key findings

  1. 01Vilon changed the expression of 36 genes, while Epithalon affected 98 genes.
  2. 02Combined treatment with Vilon and Epithalon altered the expression of 144 genes.
  3. 03Epithalon alone activated the expression of 194 genes, with some changes being as much as 6.61 times higher.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#04

Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice.

Animal
10
The study demonstrated that Epithalon reduced the incidence of chromosome aberrations in aging mice, indicating its antimutagenic effects.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#05

[Morphofunctional and molecular bases of pineal gland aging].

ReviewInfluence1.0
10
The study demonstrated that Epithalon restored melatonin secretion in the pineal gland and regulated neuroimmunoendocrine systems during aging.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#06

Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.

Animal
8
Researchers observed that Epithalon stimulated evening melatonin production and normalized cortisol circadian rhythms in old female rhesus monkeys.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#07

Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.

Animal
8
The study demonstrated that Epithalon prolonged the maximum life span of female rats exposed to natural and constant illumination while inhibiting spontaneous tumor development under natural light conditions.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#08

Effects of short peptides on lymphocyte chromatin in senile subjects.

AnimalInfluence1.0
7
The study demonstrated that Epithalon and other short peptides activated ribosome genes and decondensed chromatin in leukocytes of senile subjects aged 75-88 years.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#09

Effects of peptides on proliferative activity of retinal and pigmented epithelial cells.

In Vitro
7
The study demonstrated that epithalon stimulated the proliferative activity of retinal and pigmented epithelial cells in culture at certain concentrations.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#10

[Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors].

Animal
6
Researchers observed that chronic administration of Epithalon improved T-lymphocyte development and function in aging mice, restoring cellular balance and enhancing immune system performance.
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials involving Epithalon have been conducted to assess its safety and efficacy in humans. Additionally, the precise mechanisms by which Epithalon influences gene expression and its long-term effects on human health, particularly regarding its geroprotective and anti-carcinogenic properties, remain unclear.

Solubility

Epithalon is soluble in water and aqueous solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA. Considered a research chemical.

🇬🇧UK

Not approved by the MHRA. Considered a research chemical.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

Price Comparison

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    $19.04
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  • Peptides.netUK
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    $2.03/mg
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  • RCpeptidesEU
    50mg
    $108.00
    Price/mg
    $2.16/mg
    View

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer