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Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Fedoreyeva L I, et al. · Biochemistry. Biokhimiia · 2011
HumanInfluence3.0
33
The study demonstrated that fluorescein-labeled epithalon penetrated HeLa cells and interacted with nucleic acids, suggesting its potential role in regulating gene activity.
Key findings
- 01Peptides labeled with fluorescence were able to penetrate HeLa cells, highlighting their ability to enter cell nuclei.
- 02Different peptides showed varying effects on the fluorescence of DNA, suggesting specific interactions with nucleic acids.
- 03Some peptides preferentially bind to DNA sequences associated with cytosine methylation, which may influence gene regulation.
1 mgsubcutaneously(mouse)5 times a week from the 2nd month of life to death0.1 microg dailynot mentioned(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days starting from the 2nd month of life