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Epithalon

Epitalon · Epithalamin · Ala-Glu-Asp-Gly

Anti-Aging & LongevityPreclinical
From$1.50/mgCompare prices
MW
390.35g/mol
Formula
C14H22N4O9

Epithalon, also known as Epitalon, is a tetrapeptide composed of the amino acids alanine, glutamic acid, aspartic acid, and glycine (AEDG), originally derived from bovine pineal gland extracts. Researchers primarily study Epithalon for its potential geroprotective and neuroendocrine effects, particularly its role in modulating aging processes and enhancing telomerase activity. Key findings from studies indicate that Epithalon can induce telomerase activity and promote telomere elongation in human somatic cells, as well as decelerate aging and suppress tumor development in transgenic mice. Additionally, preclinical evidence suggests that Epithalon may improve intestinal absorption characteristics in aged rats. Despite the considerable volume of research, the quantity of physico-chemical and structural investigations of this peptide remains limited, highlighting the need for further exploration.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC14H22N4O9
Molecular Weight390.35 g/mol
CAS Number307297-39-8
PubChem CID219042

Half-Life

POOral

Poor bioavailability

Pharmacokinetic data is limited, and the compound is rapidly metabolized.

Mechanism

Mechanism of Action

Epithalon (Ala-Glu-Asp-Gly) enhances telomerase activity, leading to telomere elongation in somatic cells, which may involve reactivation of the telomerase gene. It also modulates neuroendocrine functions by influencing melatonin synthesis and altering interleukin-2 mRNA levels, although the specific receptors and complete signaling pathways involved remain unclear. Additionally, Epithalon exhibits geroprotective effects and may suppress tumorigenesis, potentially through pathways related to oxidative stress and cellular aging, but further elucidation of its precise mechanisms is needed.

Research

53 Research Publications

227

Total Citations

6

Human/RCT

1.1

Avg. Influence

2025

Latest

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#01

Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.

In VitroInfluence2.0
27
Researchers observed that Epithalon peptide induced telomerase activity and telomere elongation in human fetal fibroblasts, suggesting potential for cellular lifespan extension.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#02

Peptide promotes overcoming of the division limit in human somatic cell.

In Vitro
17
Researchers observed that Epithalon induced telomerase activity and elongated telomeres in human fetal fibroblasts, allowing cells to overcome the Hayflick limit and extend their division potential.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#03

Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.

Anisimov S V, et al. · Bulletin of experimental biology and medicine · 2002

Animal
13
The study demonstrated that Epithalon modulated the expression of 98 gene clones in mouse hearts, indicating its specific effects on gene expression.

Key findings

  1. 01Vilon changed the expression of 36 genes, while Epithalon affected 98 genes.
  2. 02Combined treatment with Vilon and Epithalon altered the expression of 144 genes.
  3. 03Epithalon alone activated the expression of 194 genes, with some changes being as much as 6.61 times higher.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#04

Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice.

Animal
10
The study demonstrated that treatment with Epithalon reduced the incidence of chromosome aberrations in senescence-accelerated mice by approximately 20% to 30% compared to age-matched controls.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#05

[Morphofunctional and molecular bases of pineal gland aging].

ReviewInfluence1.0
10
The study demonstrated that Epithalon restored melatonin secretion in the pineal gland and regulated neuroimmunoendocrine systems, countering age-related functional decline.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#06

Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.

Animal
8
Researchers observed that Epithalon prolonged the lifespan of rats exposed to natural and constant light while inhibiting spontaneous tumor development under these conditions.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#07

Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.

Animal
8
Researchers observed that Epithalon stimulated melatonin production and normalized cortisol rhythms in aging female rhesus monkeys.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#08

Effects of peptides on proliferative activity of retinal and pigmented epithelial cells.

In Vitro
7
Researchers observed that Epithalon stimulated the proliferation of retinal and pigmented epithelial cells in culture at certain concentrations.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#09

Effects of short peptides on lymphocyte chromatin in senile subjects.

AnimalInfluence1.0
7
Researchers observed that Epithalon and other peptides activated ribosome genes and decondensed chromatin in leukocytes from elderly subjects, suggesting a role in cellular aging.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#10

Effect of regulatory peptides on gene transcription.

In VitroInfluence1.0
6
Researchers observed that Epithalon directly initiates transcription of vital protein genes, highlighting its potential role in regulating gene expression.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials on Epithalon have been published, limiting the understanding of its efficacy and safety in humans. Additionally, the specific mechanisms of action remain unclear, particularly regarding the full range of biological effects and the potential long-term consequences of its use.

Solubility

Epithalon is soluble in water and aqueous solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA. Considered a research chemical.

🇬🇧UK

Not approved by the MHRA. Considered a research chemical.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

Price Comparison

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  • XL PeptidesUK
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    $19.04
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    $1.90/mg
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  • Peptides.netUK
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    $2.03/mg
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  • RCpeptidesEU
    50mg
    $108.00
    Price/mg
    $2.16/mg
    View

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer