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Vilon

Lys-Glu · KE dipeptide

Anti-Aging & LongevityPreclinical
From$0.04/mgCompare prices
MW
275.3g/mol
Formula
C11H21N3O5

Vilon is a dipeptide composed of lysine and glutamic acid, known for its potential immunomodulatory and geroprotective properties. Researchers primarily study Vilon for its effects on immune system function and aging processes. Key findings from recent studies indicate that Vilon enhances the differentiation of T-cells in thymic cells and promotes recovery of radiosensitive organs following radiation exposure. Additionally, preclinical evidence suggests that Vilon may positively influence lifespan and physical activity in animal models, while also exhibiting homeostatic effects in chronic renal failure. Current research continues to explore its molecular mechanisms and broader applications in health and disease.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC11H21N3O5
Molecular Weight275.3 g/mol
CAS Number45234-02-4
PubChem CID7010502

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and detailed studies are needed to establish precise half-life values.

Mechanism

Mechanism of Action

Vilon, a dipeptide (Lys-Glu), modulates immune responses by enhancing the differentiation of thymic T-cell precursors, likely through the activation of CD5 expression and associated signaling pathways, although the specific receptors and pathways remain to be fully elucidated. It also influences gene expression in cardiac tissue, potentially involving pathways related to cellular proliferation and survival, as indicated by its effects on transforming growth factor-beta (TGF-β) levels and microvascular permeability in chronic renal failure. Additionally, Vilon promotes thymocyte proliferation and stem cell activity in radiosensitive organs, suggesting involvement in regenerative processes, but the precise molecular mechanisms are not completely understood.

Research

39 Research Publications

146

Total Citations

10

Human/RCT

1.0

Avg. Influence

2024

Latest

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#01

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

AnimalInfluence1.0
29
The study demonstrated that Vilon treatment increased mammary cancer incidence and tumor development in HER-2/neu transgenic mice compared to control, contrasting with the protective effects of Epitalon.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#02

Solid-phase peptide synthesis on proteins.

Hansen P R, et al. · International journal of peptide and protein research · 1993

In VitroInfluence1.0
23
Researchers developed a new method for synthesizing peptides using proteins as a support structure. They successfully created specific peptide-protein conjugates and found that these conjugates could generate targeted antibodies in rabbits, which may be useful for developing precise immune responses.

Key findings

  1. 01Researchers synthesized two peptides on a protein support using a cleavable linker method.
  2. 02They obtained peptide-protein conjugates with a high number of peptide chains attached to each protein molecule.
  3. 03Immunization with one of the conjugates resulted in the production of specific antibodies in rabbits.
PubMed
#03

Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.

In Vitro
13
Researchers observed that Vilon (Lys-Glu) and other short peptides modulated gene expression related to growth and development in Nicotiana tabacum callus cultures.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#04

Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people.

In Vitro
12
Researchers observed that Vilon induces deheterochromatinization in cultured lymphocytes from older individuals, leading to the activation of ribosomal genes and the release of repressed genes.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#05

[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].

Review
10
Researchers observed that Vilon and Epithalon may regulate aging-related molecular markers CCL11 and HMGB1, potentially influencing geroprotective actions.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#06

Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells.

Animal
9
Researchers observed that dipeptide R-1 stimulated the differentiation of thymic cells into mature T-helpers and cytotoxic CD8(+) T cells, indicating its potential as an immunomodulator.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#07

Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.

Animal
7
The study demonstrated that Vilon inhibited reactive oxygen species generation in mitochondria while stimulating it in the cytosol of Drosophila melanogaster.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#08

Effect of vilon on biological age and lifespan in mice.

Khavinson V K, et al. · Bulletin of experimental biology and medicine · 2000

Animal
7
Researchers observed that subcutaneous administration of Vilon increased physical activity, prolonged lifespan, and prevented spontaneous neoplasms in female CBA mice.

Key findings

  1. 01Vilon administration increased physical activity and endurance in mice.
  2. 02The treatment prolonged lifespan and reduced the development of tumors.
  3. 03Long-term use of vilon was found to be safe with no adverse effects on development.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#09

Anti-aging peptide bioregulators induce reactivation of chromatin.

In Vitro
5
The study demonstrated that Vilon induces activation of chromatin in lymphocytes from elderly individuals, suggesting its role in enhancing gene expression.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#10

[Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results].

Review
5
Researchers observed that peptide bioregulators, including Vilon, showed potential as geroprotectors in the prevention and treatment of age-related diseases.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
Safety

Safety & Handling

Research Gaps

No clinical trials involving human subjects have been conducted to assess the safety and efficacy of Vilon, particularly regarding its long-term effects on human health. Additionally, the precise molecular mechanisms by which Vilon exerts its immunomodulatory and geroprotective effects remain unclear, necessitating further investigation into its action at the cellular and genetic levels.

Solubility

Vilon is soluble in water and has limited solubility in organic solvents such as DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer