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Vilon

Lys-Glu · KE dipeptide

Anti-Aging & LongevityPreclinical
From$0.05/mgCompare prices
MW
275.3g/mol
Formula
C11H21N3O5

Vilon, a dipeptide composed of lysine and glutamic acid (Lys-Glu), has garnered attention in the field of immunology and gerontology due to its potential immunomodulatory and age-related effects. Researchers primarily study Vilon for its role in enhancing immune responses and its impact on biological aging. Key findings indicate that Vilon can stimulate the differentiation of T-cells, enhance glucose absorption in the small intestine of aged rats, and influence gene expression in mouse heart tissue. Additionally, studies suggest that Vilon may prolong lifespan and improve physical activity in mice while exhibiting safety in chronic administration. Current research continues to explore its mechanisms of action and potential applications in cancer therapy and age-related health issues.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC11H21N3O5
Molecular Weight275.3 g/mol
CAS Number45234-02-4
PubChem CID7010502

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and detailed studies are needed to establish precise half-life values.

Mechanism

Mechanism of Action

Vilon (Lys-Glu) appears to modulate immune responses by enhancing the differentiation of T-cell precursors into CD4(+) T-helper and CD8(+) cytotoxic T cells, potentially through the activation of specific receptors involved in lymphocyte maturation, although the precise receptors and signaling pathways remain to be fully elucidated. Additionally, Vilon influences gene expression in the heart, affecting pathways related to cellular stress response and apoptosis, as indicated by its modulation of gene expression profiles in treated mice. Its effects on glucose absorption suggest involvement in transport mechanisms, possibly through modulation of GLUT transporters, but the exact signaling pathways are not clearly defined.

Research

39 Research Publications

144

Total Citations

9

Human/RCT

1.0

Avg. Influence

2024

Latest

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#01

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

AnimalInfluence1.0
29
The study demonstrated that Vilon treatment increased the incidence of mammary tumors and reduced the expression of HER-2/neu mRNA compared to control, suggesting a negative impact on tumor development in HER-2/neu transgenic mice.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#02

Solid-phase peptide synthesis on proteins.

Hansen P R, et al. · International journal of peptide and protein research · 1993

In VitroInfluence1.0
23
Researchers developed a new method for synthesizing peptides using proteins as a support structure. They successfully created specific peptide-protein conjugates and found that these conjugates could generate targeted antibodies in rabbits, which may be useful for developing precise immune responses.

Key findings

  1. 01Researchers synthesized two peptides on a protein support using a cleavable linker method.
  2. 02They obtained peptide-protein conjugates with a high number of peptide chains attached to each protein molecule.
  3. 03Immunization with one of the conjugates resulted in the production of specific antibodies in rabbits.
PubMed
#03

Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.

In Vitro
13
Researchers observed that exogenous peptides, including vilon, significantly modulate gene expression related to growth and development in tobacco callus cultures.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#04

Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people.

In Vitro
12
Researchers observed that Vilon induced deheterochromatinization in lymphocytes from older individuals, activating gene expression and protein synthesis.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#05

[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].

Review
10
Researchers observed that Vilon and Epitalon may regulate the expression of aging-related genes CCL11 and HMGB1, potentially influencing geroprotective actions.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#06

Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells.

Animal
9
Researchers observed that dipeptide R-1 significantly stimulates differentiation of thymic cells into mature T-helpers and cytotoxic CD8(+) T cells, demonstrating its potential as an immunomodulator.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#07

Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.

In Vitro
7
Researchers observed that vilon inhibited reactive oxygen species generation in mitochondria while stimulating it in the cytosol of Drosophila melanogaster, revealing age- and sex-related differences.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#08

Effect of vilon on biological age and lifespan in mice.

Khavinson V K, et al. · Bulletin of experimental biology and medicine · 2000

Animal
7
Researchers observed that chronic administration of Vilon increased lifespan and physical activity in female CBA mice while preventing spontaneous neoplasms.

Key findings

  1. 01Vilon administration increased physical activity and endurance in mice.
  2. 02The treatment prolonged lifespan and reduced the development of tumors.
  3. 03Long-term use of vilon was found to be safe with no adverse effects on development.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#09

[Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results].

Review
5
Researchers observed that peptide bioregulators, including vilon, demonstrate clinical efficacy in preventing diseases and treating individuals across various ages.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
#10

Anti-aging peptide bioregulators induce reactivation of chromatin.

In Vitro
5
The study demonstrated that Vilon, along with other peptides, activated chromatin reactivation in lymphocytes from elderly individuals, enhancing gene expression.
1 mg/kginjection(mouse)not mentioned100 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1 microg/mousesubcutaneous(mouse)5 consecutive days every month
PubMed
Safety

Safety & Handling

Research Gaps

No clinical trials involving human subjects have been conducted to evaluate the safety and efficacy of Vilon, leaving its potential therapeutic applications in humans unverified. Additionally, the long-term effects of Vilon administration on human health, particularly concerning its immunomodulatory and geroprotective properties, remain unknown.

Solubility

Vilon is soluble in water and has limited solubility in organic solvents such as DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer