Wiki · Profile

Vilon

Lys-Glu · KE dipeptide

Anti-Aging & LongevityPreclinical

MW: 275.3g/mol
Formula: C11H21N3O5

Vilon is a synthetic peptide composed of the amino acids lysine and glutamic acid, classified as a bioactive compound with potential therapeutic applications. Researchers primarily study Vilon for its effects on cancer modulation, aging, and metabolic functions. Key findings from various studies indicate that Vilon can enhance survival rates in mice with transplanted tumors, stimulate gene expression in cardiac tissue, and improve intestinal enzyme activity in aged rats. Additionally, preclinical evidence suggests that Vilon may exert beneficial effects on homeostasis during chronic renal failure by reducing specific inflammatory markers. Current research continues to explore its multifaceted roles in health and disease, highlighting its potential as a geroprotective agent and its interactions with other therapeutic compounds.

Chemical Profile

Chemical Structure

Formula	C11H21N3O5
Molecular Weight	275.3 g/mol
CAS Number	45234-02-4
PubChem CID	7010502

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and detailed studies are needed to establish precise half-life values.

Mechanism

Mechanism of Action

Vilon appears to modulate various biological processes through its effects on gene expression and enzyme activity, potentially involving the activation of signaling pathways related to cell survival and apoptosis. It has been shown to decrease transforming growth factor-beta (TGF-β) levels, which may influence the NO/cGMP pathway and enhance microvascular permeability. The precise receptors and complete signaling mechanisms through which Vilon exerts its effects remain to be fully elucidated.

Research

55 Research Publications

278

Total Citations

Human/RCT

1.0

Avg. Influence

2024

Latest

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01Top

#01

Natural and synthetic thymic peptides as therapeutics for immune dysfunction.

Animal

Researchers observed that natural thymic peptides, including Thymalin, activate T-cell differentiation and exhibit immunomodulatory effects, distinguishing them from synthetic counterparts.

5 micrograms/ratsubcutaneous(rat)5 times per week for 12 months1 mgnot specified(mouse)not specified2 and 10 ng/mlnot specified(rat)not specified5 ng/mlnot specified(rat)not specified8--16 Usubcutaneous(human)not specified0.005 mg / kgparenteral(mouse)not specified0.05 mg /kgparenteral(mouse)not specified

PubMed

02Top

#02

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

AnimalInfluence1.0

Researchers observed that Vilon treatment increased the incidence and size of mammary tumors in HER-2/neu transgenic mice, contrasting with the tumor-inhibiting effects of Epitalon.

1 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1.7 micrograms/kginjection(rat)5 days1 microg/mousesubcutaneous(mouse)5 consecutive days every month

PubMed

03Top

#03

Solid-phase peptide synthesis on proteins.

Hansen P R, et al. · International journal of peptide and protein research · 1993

In VitroInfluence1.0

Researchers developed a new method for synthesizing peptides using proteins as a support structure. They successfully created specific peptide-protein conjugates and found that these conjugates could generate targeted antibodies in rabbits, which may be useful for developing precise immune responses.

Key findings

01Researchers synthesized two peptides on a protein support using a cleavable linker method.
02They obtained peptide-protein conjugates with a high number of peptide chains attached to each protein molecule.
03Immunization with one of the conjugates resulted in the production of specific antibodies in rabbits.

PubMed

#04

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

Human

Researchers observed that five different peptides, including Thymalin, modulate inflammatory and proliferative processes in the human THP-1 monocytic cell line.

PubMed

#05

Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.

Unknown

The study demonstrated that vilon and other short peptides significantly influenced growth and differentiation of tobacco callus cultures at low concentrations.

1 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1.7 micrograms/kginjection(rat)5 days1 microg/mousesubcutaneous(mouse)5 consecutive days every month

PubMed

#06

Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.

Anisimov S V, et al. · Bulletin of experimental biology and medicine · 2002

Animal

Researchers observed that Epithalon modulates the expression of numerous genes in mouse heart tissue, indicating its specific effects on gene expression.

Key findings

01Vilon changed the expression of 36 genes, while Epithalon affected 98 genes.
02Combined treatment with Vilon and Epithalon altered the expression of 144 genes.
03Epithalon alone activated the expression of 194 genes, with some changes being as much as 6.61 times higher.

1 mgsubcutaneously(mouse)5 times a week from the 2nd month of life to death0.1 microg dailynot mentioned(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days starting from the 2nd month of life

PubMed

#07

Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people.

Human

Researchers observed that Vilon induced deheterochromatinization and activation of ribosomal genes in cultured lymphocytes from elderly individuals, indicating its role in chromatin remodeling.

1 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1.7 micrograms/kginjection(rat)5 days1 microg/mousesubcutaneous(mouse)5 consecutive days every month

PubMed

#08

[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].

Review

The study demonstrated that vilon and epitalon may regulate CCL11 and HMGB1 gene expression, potentially contributing to their geroprotective effects.

1 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1.7 micrograms/kginjection(rat)5 days1 microg/mousesubcutaneous(mouse)5 consecutive days every month

PubMed

#09

Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells.

Animal

Researchers observed that dipeptide R-1 had a stronger immunomodulating effect than dipeptide AB-O, enhancing T-cell differentiation in thymic cells.

1 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1.7 micrograms/kginjection(rat)5 days1 microg/mousesubcutaneous(mouse)5 consecutive days every month

PubMed

#10

Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.

Animal

Researchers observed that epithalon influenced reactive oxygen species generation in Drosophila melanogaster, with varying effects based on sex and age.

1 mg/kginjection(mouse)not mentioned5 ng/mlculture media(rat)not mentioned1.7 micrograms/kginjection(rat)5 days1 microg/mousesubcutaneous(mouse)5 consecutive days every month

PubMed

Safety

Safety & Handling

Research Gaps

No clinical trials involving human subjects have been conducted to evaluate the safety and efficacy of Vilon, leaving its potential therapeutic effects and long-term outcomes in humans unknown. Additionally, the precise molecular mechanisms through which Vilon exerts its effects on gene expression and biological aging remain unclear, necessitating further investigation.

Solubility

Vilon is soluble in water and has limited solubility in organic solvents such as DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

49 total

Pricing

Price Comparison

BESTResearch Peptides UKUK
1500mg
$57.15
Price/mg
$0.04/mg
View
Iron PeptidesUS
1500mg
$109.00
Price/mg
$0.07/mg
View
Iron PeptidesUS
500mg
$89.00
Price/mg
$0.18/mg
View
Iron PeptidesUS
200mg
$39.00
Price/mg
$0.20/mg
View
Umbrella LabsUS
200mg
$85.99
Price/mg
$0.43/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTResearch Peptides UKUK	1500mg	$57.15	$0.04/mg	View
Iron PeptidesUS	1500mg	$109.00	$0.07/mg	View
Iron PeptidesUS	500mg	$89.00	$0.18/mg	View
Iron PeptidesUS	200mg	$39.00	$0.20/mg	View
Umbrella LabsUS	200mg	$85.99	$0.43/mg	View

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer