Nicotinamide Mononucleotide · Beta-NMN
Nicotinamide mononucleotide (NMN) is a nucleotide derived from ribose and nicotinamide, serving as a crucial precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in cellular metabolism. Researchers primarily study NMN for its potential role in enhancing metabolic health and mitigating age-related physiological decline. Key findings from recent studies indicate that NMN supplementation can improve insulin sensitivity and metabolic function in prediabetic populations, as well as alleviate age-associated physiological decline in animal models by enhancing mitochondrial function and energy metabolism. Current research continues to explore NMN's effects on various biological processes, including its implications for aging and immune function, highlighting its potential as a significant area of investigation in metabolic and age-related disorders.
| Formula | C11H15N2O8P |
| Molecular Weight | 334.22 g/mol |
| CAS Number | 1094-61-7 |
| PubChem CID | 14180 |
| ChEMBL ID | CHEMBL610238 |
~30 minutes
Not applicable
Poor bioavailability
NMN is rapidly converted to NAD+ in tissues, impacting its pharmacokinetic profile.
Nicotinamide mononucleotide (NMN) acts as a precursor to nicotinamide adenine dinucleotide (NAD+), enhancing its biosynthesis and subsequently activating key signaling pathways such as the insulin signaling pathway, involving phosphorylation of AKT and mechanistic target of rapamycin (mTOR). NMN supplementation also up-regulates genes associated with muscle remodeling and improves mitochondrial oxidative metabolism, thereby promoting energy metabolism and insulin sensitivity. Additionally, NMN influences the CX43-PARP1 axis to mitigate aging-related blood-brain barrier dysfunction, although the complete mechanistic details remain to be fully elucidated.
4,316
Total Citations
11
Human/RCT
6.6
Avg. Influence
2023
Latest
The study demonstrated that NMN ameliorates glucose intolerance and enhances insulin sensitivity in mice with diet- and age-induced diabetes.
Mills Kathryn F, et al. · Cell metabolism · 2016
Researchers observed that long-term NMN administration mitigates age-associated physiological decline in mice, enhancing energy metabolism and insulin sensitivity without toxicity.
Key findings
Researchers observed that NMN treatment improves blood flow and increases capillary density in elderly mice by promoting SIRT1-dependent pro-angiogenic signals.
Yoshino Mihoko, et al. · Science (New York, N.Y.) · 2021
The study demonstrated that NMN supplementation increases muscle insulin sensitivity and insulin signaling in postmenopausal women with prediabetes.
Key findings
Researchers observed that mitophagy is regulated by endogenous metabolites, highlighting the interplay between cellular metabolism and mitochondrial quality control.
The study demonstrated that NMN supplementation rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis in mice.
Researchers observed that NAMPT plays a crucial role in NAD biosynthesis and metabolism, highlighting its potential as a target for cancer therapy.
Researchers developed a new method for detecting NMN and found that it is enriched in mitochondria, playing a role in delaying cell death during NAD-consuming enzyme hyperactivation.
The study demonstrated that NMN supplementation can reverse some metabolic dysfunctions caused by maternal obesity in mice, showing stronger effects on liver fat metabolism compared to exercise.
The study demonstrated that NMN supplementation enhances NK cell function and antitumor immunity by maintaining NAD+ homeostasis in activated NK cells.
While there have been promising findings regarding NMN supplementation in specific populations, there is a lack of extensive long-term human trials to assess the sustained effects and safety of NMN over time. Additionally, the precise molecular mechanisms through which NMN influences various metabolic pathways and its potential interactions with other treatments in humans remain unclear.
Solubility
NMN is soluble in water and has limited solubility in organic solvents like DMSO.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA as a medicinal product. Not a controlled substance.
🇦🇺AU
Not listed in the TGA scheduling. Considered a supplement.
🇬🇧UK
Not approved by MHRA as a medicinal product. Considered a supplement.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
50 totalTop 5 of 2 offers from 3 vendors. Prices updated daily.
See all NMN pricesLog your research cycles, set reminders and visualize serum levels.
This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer