01Top
#01
The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
ReviewInfluence6.0
189
Wiki · Profile
From$7.00/mgCompare pricesHumanin
HN · Humanin peptide
Anti-Aging & LongevityPreclinical
- MW
- 2687.2g/mol
- Formula
- C119H204N34O32S2
Humanin is a 24-amino-acid peptide encoded in the mitochondrial genome, classified as a mitochondrial-derived peptide (MDP). Researchers primarily study humanin for its potential roles in neuroprotection and metabolic regulation, particularly in the context of age-related diseases and metabolic disorders. Key findings suggest that humanin exhibits protective effects against various cytotoxic stimuli and is involved in signaling pathways that may influence insulin sensitivity and metabolic homeostasis. Additionally, studies indicate that humanin levels can be modulated by exercise and are associated with neuroprotective responses in conditions such as Alzheimer's disease. Current research continues to explore the therapeutic potential of humanin and its analogs in chronic diseases, as well as its interactions with other signaling molecules like IGF-I.
Chemical Profile
Chemical Structure
| Formula | C119H204N34O32S2 |
| Molecular Weight | 2687.2 g/mol |
| CAS Number | 330936-69-1 |
| PubChem CID | 16131438 |
Half-Life
POOral
Poor bioavailability
Pharmacokinetic data is limited, with variability depending on administration route.
Mechanism of Action
Humanin interacts with various receptors, including IGFBP-3, and is involved in modulating IGF-I signaling, which affects cellular growth and metabolism. It activates protective signaling pathways such as the PI3K/Akt pathway and AMPK pathway, promoting cytoprotection, neuroprotection, and metabolic homeostasis. The precise mechanisms of action and the full spectrum of receptors and pathways involved remain to be fully elucidated.
106 Research Publications
3,238
Total Citations
19
Human/RCT
3.1
Avg. Influence
2025
Latest
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02Top
#02
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
HumanInfluence8.0
166
Researchers observed that humanin protects retinal pigment epithelial cells from oxidative stress-induced cell death and restores mitochondrial function, indicating its potential role in preventing retinal degeneration.
2 µMnot specified(not specified)not specified
03Top
#03
Mitochondrially derived peptides as novel regulators of metabolism.
ReviewInfluence9.0
156
Researchers observed that Humanin and other mitochondrial-derived peptides regulate metabolism by reducing weight gain and increasing insulin release in mice.
04
#04
N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.
In VitroInfluence9.0
118
The study demonstrated that N-formylated Humanin acts as a ligand for formyl peptide receptors, exhibiting potent chemotactic activity and contributing to its neuroprotective effects.
2 µMnot specified(not specified)not specified
05
#05
Mitochondrial stress and mitokines in aging.
ReviewInfluence2.0
113
The study demonstrated that mitokines, including humanin, play a crucial role in mediating the health benefits of exercise and may influence aging and age-related diseases.
2 µMnot specified(not specified)not specified
06
#06
Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.
In VitroInfluence8.0
111
The study demonstrated that Humanin binds and inhibits the proapoptotic protein BimEL, contributing to its antiapoptotic properties in cell models.
07
#07
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder.
HumanInfluence7.0
103
Researchers observed that mitochondrial protein levels, including humanin, were significantly lower in plasma neuronal extracellular vesicles from participants with major depressive disorder compared to controls.
08
#08
Humanin and age-related diseases: a new link?
ReviewInfluence4.0
98
Researchers observed that Humanin is associated with various age-related diseases, suggesting its potential role in aging and longevity through interactions with the GH/IGF axis.
09
#09
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.
AnimalInfluence5.0
96
Researchers observed that humanin overexpression in C. elegans and transgenic mice increased lifespan and improved metabolic healthspan parameters, linking humanin levels to aging and healthspan.
10
#10
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.
ReviewInfluence3.0
93
Researchers concluded that Humanin serves as a critical cytoprotective peptide that regulates mitochondrial functions and suppresses apoptosis across various diseases.
Safety & Handling
Research Gaps
No randomized controlled human trials specifically investigating the therapeutic potential of humanin in various diseases have been published. Additionally, the long-term effects of humanin treatment on metabolic homeostasis and neuroprotection remain unknown, and the precise mechanisms underlying its interaction with IGF-I and its role in cancer progression and chemoresistance are still unclear.
Solubility
Humanin is soluble in water and aqueous buffers.
Storage & Handling
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
Legal Status
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA schedules.
🇬🇧UK
Not approved by the MHRA as a medicinal product.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Community Insights
Publications per Year
49 totalPricing
Price Comparison
- BESTUmbrella LabsUS10mg$69.99Price/mg$7.00/mg
- Peptide ProsUS5mg$48.40Price/mg$9.68/mg
- Baltic BioLabsEU5mg$51.83Price/mg$10.37/mg
- Biolab ShopUS5mg$53.07Price/mg$10.61/mg
- LabSourcedUS10mg$119.00$101.15Price/mg$11.90$10.12/mgView−15% · PEPSTACK
| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTUmbrella LabsUS | 10mg | $69.99 | $7.00/mg | |
Peptide ProsUS | 5mg | $48.40 | $9.68/mg | |
Baltic BioLabsEU | 5mg | $51.83 | $10.37/mg | |
Biolab ShopUS | 5mg | $53.07 | $10.61/mg | |
LabSourcedUS | 10mg | $119.00$101.15 | $11.90$10.12/mg | View−15% · PEPSTACK |
Top 5 of 21 offers from 14 vendors. Prices updated daily.
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Legal Disclaimer
This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer