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Humanin

HN · Humanin peptide

Anti-Aging & LongevityPreclinical
From$9.68/mgCompare prices
MW
2687.2g/mol
Formula
C119H204N34O32S2

Humanin is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome, recognized for its role as a signaling molecule that mediates cellular stress responses. Researchers primarily study humanin for its potential protective effects against various cytotoxic stimuli and its implications in metabolic and neurodegenerative diseases. Key findings suggest that humanin can enhance insulin sensitivity, reduce obesity, and exert neuroprotective effects, particularly in the context of exercise and aging. Additionally, preclinical evidence indicates that humanin may serve as a biomarker for chronic diseases and has therapeutic potential in conditions such as cancer and cardiovascular disorders. Current research is focused on elucidating the mechanisms of action of humanin and exploring its analogs for therapeutic applications.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC119H204N34O32S2
Molecular Weight2687.2 g/mol
CAS Number330936-69-1
PubChem CID16131438

Half-Life

POOral

Poor bioavailability

Pharmacokinetic data is limited, with variability depending on administration route.

Mechanism

Mechanism of Action

Humanin (HN) acts primarily through the activation of the PI3K/Akt signaling pathway, which promotes cell survival and protects against apoptosis and oxidative stress. It is known to interact with specific receptors, including the insulin receptor and the formyl peptide receptor 2 (FPR2), facilitating metabolic regulation and cytoprotection. Although the precise mechanisms of HN's action are still being elucidated, its involvement in mitochondrial function, neuroprotection, and metabolic homeostasis is well established.

Research

75 Research Publications

2,978

Total Citations

12

Human/RCT

4.5

Avg. Influence

2025

Latest

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#01

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Lee Changhan, et al. · Cell metabolism · 2015

AnimalInfluence63.0
627
Researchers observed that the mitochondrial-derived peptide MOTS-c regulates insulin sensitivity and metabolic homeostasis, preventing insulin resistance and obesity in mice.

Key findings

  1. 01MOTS-c is a 16-amino-acid peptide that influences metabolic health by targeting skeletal muscle.
  2. 02MOTS-c treatment in mice reduced insulin resistance associated with aging and high-fat diets.
  3. 03The study suggests that mitochondria may actively contribute to metabolic regulation through peptides encoded in their DNA.
15 mg/kgintraperitoneal(rat)3 weeks30 mg/kgintraperitoneal(rat)not specified
PubMed
#02

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

In VitroInfluence7.0
158
The study demonstrated that Humanin protected human retinal pigment epithelial cells from oxidative stress-induced cell death and restored mitochondrial function, indicating its potential role in preventing retinal degeneration.
PubMed
#03

N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.

In VitroInfluence9.0
118
Researchers observed that humanin and its N-formylated variant activate formyl peptide receptors, demonstrating strong chemotactic activity and potential neuroprotective effects.
PubMed
#04

Mitochondrial-derived peptides in energy metabolism.

ReviewInfluence3.0
109
The review highlighted that mitochondrial-derived peptides, including Humanin, are sensitive to metabolic changes and may play a role in restoring cellular homeostasis in metabolic disorders.
PubMed
#05

Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.

In VitroInfluence7.0
108
Researchers observed that humanin binds and inhibits the proapoptotic protein BimEL, contributing to its cytoprotective effects against apoptosis.
PubMed
#06

Humanin and age-related diseases: a new link?

ReviewInfluence4.0
99
Researchers observed that humanin is associated with various age-related diseases, suggesting its potential role in aging and the development of therapeutic strategies.
PubMed
#07

Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder.

In VitroInfluence5.0
89
Researchers observed lower levels of mitochondrial proteins, including humanin, in neuronal extracellular vesicles from major depressive disorder patients, indicating potential biomarkers for the condition.
PubMed
#08

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.

AnimalInfluence5.0
88
Researchers observed that humanin overexpression in C. elegans increases lifespan and improves metabolic healthspan in mice, linking it to longevity.
PubMed
#09

Mitochondrial stress and mitokines in aging.

ReviewInfluence1.0
88
The study demonstrated that alterations in mitokine levels, including humanin, are associated with aging and may influence the development of age-related diseases.
PubMed
#10

Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.

ReviewInfluence2.0
86
The study demonstrated that humanin exerts cytoprotective effects against apoptosis in various cell types, suggesting its potential as a therapeutic target for multiple apoptosis-related diseases.
PubMed
Safety

Safety & Handling

Research Gaps

No comprehensive human clinical trials have been conducted to evaluate the long-term effects of humanin supplementation on metabolic health and neuroprotection in diverse populations. Additionally, the precise molecular mechanisms underlying humanin's protective effects against various cytotoxic stimuli and its role in cancer progression remain poorly understood, necessitating further investigation.

Solubility

Humanin is soluble in water and aqueous buffers.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

48 total
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Pricing

Price Comparison

  • BESTPeptide ProsUS
    5mg
    $48.40
    Price/mg
    $9.68/mg
    View
  • LabSourcedUS
    10mg
    $119.00
    $101.15
    Price/mg
    $11.90$10.12/mg
    View−15% · PEPSTACK
  • RCpeptidesEU
    10mg
    $135.00
    Price/mg
    $13.50/mg
    View
  • Baltic BioLabsEU
    5mg
    $106.92
    Price/mg
    $21.38/mg
    View
  • bulkpeptidesupply.comUS
    10mg
    $475.00
    Price/mg
    $47.50/mg
    View

Top 5 of 23 offers from 13 vendors. Prices updated daily.

See all Humanin prices
Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer